枸橼酸舒芬太尼喷鼻用于术后镇痛的临床观察  

Clinical research of intranasal sufentanil citrate for postoperative analgesia

作　　者：杨又春[1] 李广田[1] 王汉[2] 

机构地区：[1]中山大学附属第五医院麻醉科,广东珠海519000 [2]中山大学附属第五医院神经外科,广东珠海519000

出　　处：《中国医药科学》2011年第13期13-14,共2页China Medicine And Pharmacy

基　　金：广东省医学科研基金(编号:A2007226)

摘　　要：目的探讨枸橼酸舒芬太尼喷鼻用于术后镇痛的有效性和安全性。方法选取50例ASAⅠ或Ⅱ级椎管内麻醉下腹部手术后的女性患者,将枸橼酸舒芬太尼经鼻腔给药,每位患者左右各1喷(每喷量为100μL,2喷含舒芬太尼10μg),观察各时间点的疼痛评分、血压、心率、SpO2和不良反应。结果舒芬太尼喷鼻后,94%的患者术后疼痛得到明显的缓解,5～10 min后疼痛明显减轻,30 min时接近最大镇痛效应,有效时间至少持续120 min,HR、SBP、DBP、SpO2无显著变化,未发生明显不良反应。结论枸橼酸舒芬太尼喷鼻用于术后镇痛,疗效确切,效果显著。成人10μg/次(2喷)的舒芬太尼是比较合适的剂量,未发生明显不良反应。Objective To evaluate the safety and efficacy of intranasal sufentanil citrate for postoperative analgesia.Methods Fifty female patients,ASA I–II,scheduled for abdominal operation under intrathecal anesthesia,were included when postoperative pain treatment was required.A nasal puff device delivering a constant volume of 100μL was used.Each patient received a dose of 10μg/2 puff.Evaluation of pain intensity（and analgesic effect） and adverse reactions were recorded.Blood pressure,heart rate and pulse oximetry were also recorded.Results After nasal administration of 10μg/2 puff sufentanil,94% of the patients attained satisfactory analgesia at least 120min,with onset of pain relief after 5-10min and efficacy achieved after 30 min.Blood pressure,heart rate and oxygen saturation remained stable throughout the observation period without remarkable adverse reactions.Conclution Intranasally administered sufentanil citrate offer a rapid,effective method of postoperative analgesia without remarkable adverse event.A dose of 10μg/2 puff of sufentanil may be suitable in an adult patient.

关 键 词：枸橼酸舒芬太尼 经鼻给药 术后镇痛 

分 类 号：R452[医药卫生—治疗学]