TLR-induced activation of Btk- Role for endosomal MHC class II molecules revealed  

作　　者：Joan Ni Gabhann Caroline A Jefferies 

机构地区：[1]Molecular and Cellular Therapeutics and RSCI Research Institute, Royal College of Surgeons in Ireland, Dublin, Ireland

出　　处：《Cell Research》2011年第7期998-1001,共4页细胞研究（英文版）

摘　　要：MHC molecules have been shown to play key roles in the immune system including regulating T-cell repertoire development through the process of positive and negative selection. MHC molecules also function to bridge the innate and adaptive immune system through the presentation of processed antigenic peptides to T-cells. Strategies employed by tumour cells and viruses that downregulate expression of MHC molecules to avoid immune detection highlight the crucial role that these molecules play in maintaining immune homeostasis.

关 键 词：分子表达 MHC TLR 激活 诱导 免疫系统 选择过程 先天免疫 

分 类 号：Q254[生物学—细胞生物学] S828.2[农业科学—畜牧学]