Long-term survival of exogenous embryonic stem cells in adult bone marrow  

作　　者：Yueying Li Yanfeng Liu Jing He Fengchao Wang Sheng Liu Yu Zhang Zhaohui Kou Zhenyu JU Guoguang Zheng Jing Xu Weiping Yuan Shaorong Gao Tao Cheng 

机构地区：[1]State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing Road, Tianjin 300020, China [2]National Institute of Biological Sciences, #7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China [3]Max-Planck-Partner Group on Stem Cell Aging, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing, China [4]Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Beo'ing, China

出　　处：《Cell Research》2011年第7期1148-1151,共4页细胞研究（英文版）

基　　金：grateful to Cheng Zhan, Lanlan Gu （National Institute of Biological Sciences, China）, and Jinhong Wang （Institute of Hematology, CAMS, China） for their assistance regarding two-photon microscopy and flow cytometric analysis. The work was supported by grants from the Ministry of Science and Technology of China （2011 CB964801, 2009CB521803, 2010DFB30270, 2008AA022311, 2008AA1011005 and 2010CB944900） and research funds from the Tianjin Science and Technology Commission （07JCZDJC10600 and 09ZCZDSF03800）. T.C. was a recipient of the Yangzi River Scholarship from the Ministry of Education of China （2007-JGT-08）, the Outstanding Young Scholar Award from the National Natural Science Foundation of China （NSFC; 30825017）, and the Scholar Award from the Leukemia and Lymphoma Society.

摘　　要：Dear Editor, Embryonic stem cell （ESC） is an attractive and promising source in regenerative medicine. However, current technologies for ESC differentiation do not ensure complete or synchronized conversion of ESCs into a specific functional tissue type for therapeutic purposes. Thus, un- differentiated ESCs, though few, may be still contained in the therapeutic ESC derivatives. It is yet to be determined whether un-differentiated ESCs can survive in adult organs/tissues for a long term in vivo.

关 键 词：胚胎干细胞 成人骨髓 外源性 组织类型 ESC 再生医学 同步转换 长期存活 

分 类 号：Q813[生物学—生物工程] Q421