骨髓基质细胞移植治疗缺血性脑损伤的机制研究进展  

Progress of treatment of ischemic brain injury by transplantation of bone marrow stromal cells

作　　者：李文慧[1] 席焕久[1] 

机构地区：[1]辽宁医学院人类学研究所,辽宁锦州121001

出　　处：《解剖科学进展》2011年第4期396-398,共3页Progress of Anatomical Sciences

基　　金：辽宁省教育厅自然基金项目(No.05L129)

摘　　要：骨髓基质细胞具有高度的增殖能力和神经分化潜能,可用于治疗缺血性脑损伤,其作用机制可能是通过增殖、分化替代受损神经细胞并整合到原有的神经网络当中,分泌生长因子和神经营养因子促进内源性神经干细胞的增殖与分化、促进血管发生、增强轴突可塑性、减少神经细胞凋亡等,以促进神经功能恢复。Bone marrow stroma cells have high capabilities of proliferation and nerve differentiation,and available for the treatment of ischemic brain injury.The mechanisms of the action may be that bone marrow stroma cells differentiate into nerve cells,rebuild neural network and secrete growth factors and neurotrophic factors to promote the proliferation and differentiation of endogenous nerve stem cells and the vasculogenesis,to enhance the axon plasticity and reduce apoptosis of ischemic zone and promote the recovery of neural function.

关 键 词：缺血性脑损伤 骨髓基质细胞 移植治疗 神经分化潜能 内源性神经干细胞 神经细胞凋亡 增殖能力 神经营养因子 

分 类 号：R331.22[医药卫生—人体生理学]