非人灵长类局部脑缺血动物模型研究现状  

Current status of research on focal cerebral ischemia models in non-human primates

作　　者：吴婷婷[1] 屈会化[1] 王雪茜[1] 赵琰[1] 卢建秋[1] 王庆国[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《中国实验动物学报》2011年第3期263-268,共6页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然基金重大研究计划面上项目(NO.90709051);国际科技合作项目(NO.007DFA30730);国家"重大新药创制"专项课题(2009ZX09102-126)

摘　　要：非人灵长类动物在种系发生上较啮齿类更接近于人类,用来制备局部脑缺血模型可以更好的拟合临床症状和机理。通过对国内外非人灵长类动物局部脑缺血模型的制备方法和应用现状进行收集、分类和述评,展望非人灵长类动物模型的应用前景,尤其是利用低等灵长类动物树鼩研究缺血性中风的优势。Non-human primates is closer to human than rodents in phylogenetics so that they could be more compatible to simulate clinical symptoms and the mechanism.In this article,we looked ahead at the prospect of non-human primates models,especially the advantage of the use of tree shrews in focal cerebral ischemia research area through reviewing the methods and application of focal cerebral ischemia models in non-human primates at home and abroad.

关 键 词：局部脑缺血 动物模型 非人灵长类动物 

分 类 号：Q95-33[生物学—动物学]