Effects of gamma-aminobutyric acid receptors on muscarinic receptor-mediated free calcium ion levels in the facial nucleus following facial nerve injury  

作　　者：Guangfeng Jiang Dawei Sun Rui Zhou Fugao Zhu Yanqing Wang Xiuming Wan Banghua Liu 

机构地区：[1]Department of Otolaryngology & Head and Neck Surgery, Affiliated Hospital of Medical School, Qingdao University, Qingdao 266003, Shandong Province, China [2]School of Public Health, Shandong University, Jinan 250012, Shandong Province, China [3]Department of Scientific Teaching, Affiliated Hospital of Medical School, Qingdao University, Qingdao 266003, Shandong Province, China [4]Department of Otolaryngology & Head and Neck Surgery, Union Hospital of Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China

出　　处：《Neural Regeneration Research》2011年第11期855-859,共5页中国神经再生研究（英文版）

基　　金：the Youth Research Foundation of Qingdao University, No. 2007

摘　　要：Muscarinic receptors and nicotine receptors can increase free calcium ion levels in the facial nucleus via different channels following facial nerve injury. In addition, γ-aminobutyric acid A （GABAA） receptors have been shown to negatively regulate free calcium ion levels in the facial nucleus by inhibiting nicotine receptors. The present study investigated the influence of GABAA, γ-aminobutyric acid B （GABAB） and C （GABAc） receptors on muscarinic receptors in rats with facial nerve injury by confocal laser microscopy. GABAA and GABAB receptors exhibited significant dose-dependent inhibitory effects on increased muscarinic receptor-mediated free calcium ion levels following facial nerve injury. Results showed that GABAA and GABAB receptors negatively regulate muscarinic receptor effects and interplay with cholinergic receptors to regulate free calcium ion levels for facial neural regeneration.Muscarinic receptors and nicotine receptors can increase free calcium ion levels in the facial nucleus via different channels following facial nerve injury. In addition, γ-aminobutyric acid A （GABAA） receptors have been shown to negatively regulate free calcium ion levels in the facial nucleus by inhibiting nicotine receptors. The present study investigated the influence of GABAA, γ-aminobutyric acid B （GABAB） and C （GABAc） receptors on muscarinic receptors in rats with facial nerve injury by confocal laser microscopy. GABAA and GABAB receptors exhibited significant dose-dependent inhibitory effects on increased muscarinic receptor-mediated free calcium ion levels following facial nerve injury. Results showed that GABAA and GABAB receptors negatively regulate muscarinic receptor effects and interplay with cholinergic receptors to regulate free calcium ion levels for facial neural regeneration.

关 键 词：injury of facial nerve γ-aminobutyric acid A receptor γ-aminobutyric acid B receptor muscarinic receptor facial nucleus calcium ion peripheral nerve injury neural regeneration 

分 类 号：Q425[生物学—神经生物学] S481.1[生物学—生理学]