Cognitive improvement following transvenous adipose-derived mesenchymal stem cell transplantation in a rat model of traumatic brain injury  

作　　者：Dongfei Li Chun Yang Rongmei Qu Huiying Yang Meichun Yu Hui Tao Jingxing Dai Lin Yuan 

机构地区：[1]Key Laboratory of Tissue Construction and Detection of Guangdong Province, Department of Anatomy, Southern Medical University,Guangzhou 510515, Guangdong Province, China

出　　处：《Neural Regeneration Research》2011年第10期732-737,共6页中国神经再生研究（英文版）

基　　金：the National Basic Research Program of China(973Program),No.2007CB512705;the General Program for Youths of the National Natural Science Foundation of China,No.30801464

摘　　要：The effects of adipose-derived mesenchymal stem cell (ADMSC) transplantation for the repair of traumatic brain injury remain poorly understood. The present study observed neurological functional changes in a rat model of traumatic brain injury following ADMSC transplantation via the tail vein. Cell transplants were observed in injured cerebral cortex, and expression of brain-derived nerve growth factor was significantly increased in the injured hippocampus following transplantation. Results demonstrated that transvenous ADMSC transplants migrated to the injured cerebral cortex and significantly improved cognitive function.The effects of adipose-derived mesenchymal stem cell （ADMSC） transplantation for the repair of traumatic brain injury remain poorly understood. The present study observed neurological functional changes in a rat model of traumatic brain injury following ADMSC transplantation via the tail vein. Cell transplants were observed in injured cerebral cortex, and expression of brain-derived nerve growth factor was significantly increased in the injured hippocampus following transplantation. Results demonstrated that transvenous ADMSC transplants migrated to the injured cerebral cortex and significantly improved cognitive function.

关 键 词：adipose-derived mesenchymal stem cells traumatic brain injury brain-derived nerve growth factor CORTEX stem cell transplantation neural regeneration 

分 类 号：Q813[生物学—生物工程] F407.7[经济管理—产业经济]