Midbrain enkephalin expression in a rat migraine model following intragastric scorpion powder administration  

作　　者：Gang Yao Xiangdan Luo Dihui Ma Tingmin Yu 

机构地区：[1]Department of Neurology, First Hospital, Jifin University, Changchun 130021, Jifin Province, China [2]Department of Neurology, Second Hospital, Jilin University, Changchun 130041, Jilin Province, China [3]Department of Food Science, College of Quartermaster Technology, Jilin University, Changchun 130000, Jilin Province, China

出　　处：《Neural Regeneration Research》2011年第12期903-907,共5页中国神经再生研究（英文版）

摘　　要：Scorpion has strong analgesic effects, but its analgesic mechanisms remain unclear. This study investigated the effects of scorpion powder on enkephalin expression in the midbrain of rats with nitroglycerin-induced migraine at mRNA and protein levels. Results confirmed that migraine rat abnormal behavior was significantly improved, and proenkephalin mRNA expression was significantly increased following treatment with scorpion. The number of methionine-enkephalin- positive cells in the migraine rats following treatment with scorpion was significantly increased, but no significant difference in the number of leucine-enkephalin-positive cells was detectable compared with migraine and normal rats. Taken together, these results show that scorpion exerts potentially beneficial effects by promoting enkephalin expression in nitroglycerin-induced migraine rats.Scorpion has strong analgesic effects, but its analgesic mechanisms remain unclear. This study investigated the effects of scorpion powder on enkephalin expression in the midbrain of rats with nitroglycerin-induced migraine at mRNA and protein levels. Results confirmed that migraine rat abnormal behavior was significantly improved, and proenkephalin mRNA expression was significantly increased following treatment with scorpion. The number of methionine-enkephalin- positive cells in the migraine rats following treatment with scorpion was significantly increased, but no significant difference in the number of leucine-enkephalin-positive cells was detectable compared with migraine and normal rats. Taken together, these results show that scorpion exerts potentially beneficial effects by promoting enkephalin expression in nitroglycerin-induced migraine rats.

关 键 词：PROENKEPHALIN METHIONINE-ENKEPHALIN LEUCINE-ENKEPHALIN MIGRAINE SCORPION rats 

分 类 号：S865.49[农业科学—野生动物驯养] Q426[农业科学—畜牧兽医]