子痫前期患者血清脂质过氧化物与血脂变化的相关性研究  

Correlations between Malondialdehyde and Lipid Profiles in Pre-eclampsia Patients

作　　者：岳文芳[1] 李季滨[1] 李丽[1] 范爱华 王丽琴 

机构地区：[1]河北省人民医院妇产科,河北省石家庄市050051 [2]武安市医院妇产科

出　　处：《中国全科医学》2011年第21期2435-2436,共2页Chinese General Practice

基　　金：河北省2008年医学科学研究重点课题(08219)

摘　　要：目的探讨血清中脂质过氧化物丙二醛(MDA)对子痫前期(PE)患者血脂变化的影响及其与病情严重程度的关系。方法入选60例PE孕妇为试验组,健康孕晚期妇女40例为对照组。分别检测两组受试者血清中MDA与血脂变化情况。结果试验组孕妇血清中MDA水平(6.13±1.61)nmol/L显著高于对照组(4.42±0.88)nmol/L(P<0.05),其中重度PE组MDA水平(7.11±1.52)nmol/L较轻度PE组(5.16±1.02)nmol/L明显升高(P<0.05),轻度PE组亦高于对照组(P<0.05)。试验组孕妇血清三酰甘油(TG)和低密度脂蛋白胆固醇(LDL-C)比对照组高,而高密度脂蛋白胆固醇(HDL-C)比对照组低(P<0.05)。轻度PE组TG、HDL-C与对照组比较差异有统计学意义(P<0.05)。轻度PE组LDL-C与对照组比较差异无统计学意义(P>0.05);而重度PE组LDL-C与对照组比较差异有统计学意义(P<0.05)。结论 MDA、血脂与PE发病及病情轻重程度有关。Objective To investigate the relationships between Malondialdehyde（MDA）and lipid profiles and the severity of the condition in pre-eclampsia patients.Methods Sixty pregnant women with PE and 40 healthy women in their late pregnancy were enrolled and evaluate the changes of MDA levels and lipid profile in the serum of these subjects.Results Serum MDA levels in the study group（6.13±1.61 nmol/L） were significantly higher than those in the control group（4.42±0.88 nmol/L）（P0.05）.Compared with those of the mild preeclampsia group（5.16±1.02 nmol/L）,serum MDA levels of the severe preeclampsia group（7.11±1.52 nmol/L）were significantly higher（P0.05）.Still,serum MDA levels in the mild preeclampsia group were significantly higher than those in the control group（P0.05）.Serum TG and LDL-C levels in the study group were significantly higher than those in the control group（P0.05）.Serum HDL-C levels in the study group were significantly lower than those in the control group（P0.05）.Conclusion The abnormality of MDA levels and lipid profile of patients with pre-eclampsia are related to the pathogenesis and the severity of pre-eclampsia.

关 键 词：先兆子痫 脂质过氧化物 脂蛋白 

分 类 号：R714.244[医药卫生—妇产科学]