磁性生物陶瓷生物愈合机制的实验研究  

Biological healing mechanism of magnetic porous Ca3 （ PO4 ）2： an experimental study

作　　者：娄朝晖[1] 董宪杰[1] 陈安民[2] 夏正材[3] 孙淑珍[4] 程涛 

机构地区：[1]郑州大学第一附属医院骨科,450000 [2]华中科技大学同济医学院附属同济医院骨科 [3]华中科技大学物理系 [4]武汉理工大学 [5]郑州市口腔医院

出　　处：《中华创伤杂志》2011年第7期659-662,共4页Chinese Journal of Trauma

基　　金：湖北省科技攻关汁划重点资助项目（2001AA307B10）

摘　　要：目的研究磁性生物陶瓷[Magnetic Porous Ca3（PO4）2，MPTCP]优良的生物愈合能力的形成原因与理论基础。方法MPTCP磁化曲线的测定：选取7块2cm×1cm×0．5cm的MPTCP样本，分别置于材料物理系统测试42次，取其均值测定磁性生物陶瓷磁化曲线；采用惠普RLC阻抗谱仪4284A的附件16451B测定MPTCP电介质谱与介电损耗谱，采用四线法测量MPTCP电阻抗。结果MPTCP具有较好的顺磁性，外磁场在-10000～10000Oe区间表现：磁化快，退磁也快；饱和磁化强度约为0．84253emu／g。电介质谱与介电损耗谱研究：电磁波为10^3～10^4Hz区间介电常数有一明显的高峰性改变；相应区域的介电损耗达到高峰。电阻抗测试结果较为明显的是，当外部电磁波的频率≤1000Hz时，MPTCP的电阻抗较大，而当电磁波的频率≥1000Hz时，电阻抗相对较小，且较为稳定。结论对研究结果的分析表明自然磁场与生活磁场的作用能够导致MPTCP磁、电状态的改变：即MPTCP的磁化强度改变以及感应电流、感应电动势的产生；感应电流与感应电动势进而促进材料与骨的生物愈合可能是MPTCP具有良好的生物愈合能力的丰霉原因。Objective To study the causes and theoretical basis for good bone healing ability of magnetic Porous Ca3 （ PO4 ） 2 （MPTCP）. Methods Seven MPTCP specimens with size of 2 cm × 1 cm × 0.5 cm were placed in the material physical system for detecting 42 times and the mean detection value was used to measure the MPTCP curve. The attachment 16451 B of impedance spectrometer HP RLC was employed to measure dielectric spectroscopy and dielectric spectroscopy of MPTCP. Four-wire method was used to measure the impedance of MPTCP. Results The magnetic intensity changed rapidly when magnetic field was in a range of -10,000-10,000 0e. The peak of dielectric spectroscopy and impedance of magnetic bioceramics was in the range of 103-104 nz. When the external electromagnetic wave of frequency was ≤ 1 000 Hz, electrical impedance of MPTCP was large ; while when the electromagnetic wave frequency was ≥ 1 000 Hz, the impedance was relatively small and stable. Conclusion The environ- mental magnetic fields may change the magnetic and electric behavior of MFFCP and promote the biological healing, which may be the cause for the good bone healing ability of MFFCP.

关 键 词：骨折愈合 陶瓷制品 

分 类 号：R686[医药卫生—骨科学]