齐墩果酸对阿霉素抑制离体猪毛囊生长的影响  

Effect of oleanolic acid on the growth of pig hair follicles inhibited by adriamycin in vitro

作　　者：张兴洪[1] 刘彦群[1] 魏志平[1] 田美华[1] 

机构地区：[1]徐州医学院附属医院皮肤科,江苏徐州221002

出　　处：《中国麻风皮肤病杂志》2011年第6期384-386,共3页China Journal of Leprosy and Skin Diseases

基　　金：江苏省中医药局中医药科研项目(编号:H05103)

摘　　要：目的:评价齐墩果酸对阿霉素抑制离体培养猪毛囊生长的影响。方法:离体的生长期猪毛囊用Williams E培养液和不同浓度的齐墩果酸培养,24 h后加入3μmol/L阿霉素,显微镜下观察各组毛囊生长和毛球部形态变化。结果:培养第5天,阿霉素显著抑制猪毛囊生长,毛囊出现退行性变化,而20、40、80μmol/L的齐墩果酸均能改善猪毛囊生长(P<0.C5),毛囊仍维持生长期形态。结论:齐墩果酸能在一定程度上减轻阿霉素对离体培养的猪毛囊生长的抑制作用。Objective： To evaluate the effect of oleanolic acid on the growth of pig hair follicles inhibited by adriamycin in vitro. Method： After pig hair follicles in anagen stage were cultured with Williams E medium and different concentrations of oleanolic acid for 24 h, 3μmol/L adriamycin was added for co - culture. Hair follicles growth and morphological changes in hair follicle bulb were observed by microscope. Results： On day 5 after culture, the growth of pig hair follicles was inhibited by adriamycin, while the growth of pig hair follicles was significantly increased when co - cultured with 20μmol/L, 40μmol/L and 80 μmol/L oleanolic acid （P 〈 0.05）. The morphological observation revealed that the hair follicles in adriamycin group presented as catagen/telogen stage, while the hair follicles in oleanolic acid groups were still maintaining in anagen stage. Conclusion： Oleanolic acid can partially reduce the inhibitive effect of adriamycin on the growth of pig hair follicles and delay the development of catagen/telogen stages.

关 键 词：齐墩果酸 阿霉素 猪 毛囊 

分 类 号：R965[医药卫生—药理学]