早期梅毒血清IFN-γ、IL-18和IL-13水平检测  

Detection of serum levels of IFN - γ, IL - 18 and IL - 13 in patients with early syphilis

作　　者：杜军兴[1] 涂晨[2] 李文竹[1] 

机构地区：[1]兰州大学第二医院皮肤科,兰州730030 [2]西安交通大学第二附属医院皮肤病性病科,西安710004

出　　处：《中国麻风皮肤病杂志》2011年第6期398-400,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的:评价IFN-γ、IL-18和IL-13在早期梅毒细胞免疫中的作用。方法:采用DAbSELISA法检测50例早期梅毒患者和52例健康人血清IFN-γ、IL-18和IL-13水平。结果:早期梅毒组IFN-γ、IL-18和IL-13水平高于对照组(P<0.05);一期梅毒组IFN-γ、IL-18水平高于二期、早期潜伏梅毒组和对照组(均P<0.05),二期梅毒组IL-13水平高于一期梅毒组和对照组(P<0.01),低于早期潜伏梅毒组(P<0.05);RPR试验滴度与IFN-γ、IL-18和IL-13不相关(P>0.05);IFN-γ和IL-13负相关(P<0.05),IFN-γ和IL-18正相关(P<0.01),IL-18和IL-13不相关(P>0.05)。结论:早期梅毒血清IFN-γ、IL-18和IL-13的变化可能是导致早期梅毒发生Th1/Th2免疫应答失衡的重要原因。Objective： To assess the role of IFN -γ, IL - 18 and IL - 13 in the cellular immunity of early syphilis. Method： The serum levels of IFN -γ, IL - 18 and IL - 13 were measured by DAbS - ELISA in 50 patients with early syphilis and 52 healthy individuals. Results： The serum levels of IFN - γ, IL- 18 and IL- 13 were higher in early syphilis than in control group （ P 〈0.05）, serum level of/FN-γ and IL- 18 was higher in primary syphilis than in secondary syphilis, early latent syphilis and control group （P 〈 0.05）. The serum level of IL- 13 was higher in secondary syphilis than in primary syphilis and control group （ P 〈 0.01）, but lower than in early latent syphilis （ P 〈 0.05） ; The titer of RPR test was not correlated with the serum levels of IFN - γ, IL- 18 and IL - 13 （ P 〉 0.05） ; The correlation was negative between IFN- γand IL- 13 （ P 〈 0.05）, positive between IFN- γ and IL- 18 （ P 〈0.01）. There was no correlation between IL- 18 and IL- 13 （ P 〉 0.05）. Conclusion： The changes of IFN- γ, IL- 18 and IL- 13 may be involved in the imbalance of Th1/Th2 immune responses in early syphilis.

关 键 词：早期梅毒 干扰素-Γ 白介素-18 白介素-13 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]