海藻酸钠交联肝素涂层在体外循环及人工心肺支持装置管路中的应用  

Cross-linked alginate/heparin coated cardiopulmonary bypass support device

作　　者：刘东[1] 李彤[2] 于美丽[2] 胡晓旻[2] 段大为[2] 李鑫[2] 

机构地区：[1]天津医科大学三中心临床学院天津市肝胆疾病研究所,天津市300170 [2]天津市第三中心医院,天津市300170

出　　处：《中国组织工程研究与临床康复》2011年第21期3855-3858,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：天津市科委支撑项目(09JCYBJC27600);课题名称:新型体外膜肺氧合耗材研制基础研究~~

摘　　要：背景:目前国内体外循环心脏手术使用的非肝素涂层管路和插管对血液破坏大、炎性反应重,影响心脏手术后患者的恢复和生存。目的:采用生物医用高分子材料研制新型体外循环管道肝素涂层技术,并对其稳定性及抗凝血性能进行研究。方法:利用CaCl2将活化医用聚氯乙烯体外循环管道内表面修饰形成Ca2+膜,并与海藻酸钠和肝素交联;其中Ca2+与海藻酸钠、肝素钠中的Na+反应,从而使线型聚合物分子发生交联,形成化学交联海藻酸钠-肝素复合物的网状结构,实现生物型材料肝素化涂层。结果与结论:CaCl2修饰活化医用聚氯乙烯体外循环管道并与海藻酸钠和肝素交联反应,形成生物型高分子材料肝素化涂层管道,试验证明肝素化涂层管道具有良好的血液相容性、稳定性、抗凝血性能,可满足体外循环中短期转流的要求。BACKGROUND：Currently,non-heparin-coated pipe and tube have a great impact on internal cardiopulmonary bypass（CPB）cardiac surgery,which can cause blood damage,heavy inflammatory response,and influence the postoperative recovery and survival of patients.OBJECTIVE：To develop a new heparin-coated CPB pipe by using the bomedical polymer materials,and to study its stability and performance of anticoagulant.METHODS：CaCl2 was used to form Ca2＋membrane for modifying the inner surface of medical polyvinyl chloride（PVC） pipe cross-linking with sodium alginate and heparin.The Ca2＋ reacted with Na＋ which was in the sodium alginate and heparin,so that the linear polymer cross-linking molecules were to form chemical cross-linked sodium alginate-heparin complex network structure,a type of biomaterial heparin coating.RESULTS AND CONCLUSION：CaCl2 modified activated medical PVC cardiopulmonary bypass pipe reacting with heparin and sodium alginate to bring out the cross-linking reaction and form biological polymers heparin-coating pipe.The heparin-coated pipe has been proved that it has good blood compatibility,stability,anti-coagulation performance to meet short-term extracorporeal circulation bypass.

关 键 词：体外循环 肝素涂层 海藻酸钠 抗凝血功能 稳定性 血液相容性 

分 类 号：R318[医药卫生—生物医学工程]