七氟烷对女性患者压力反射敏感性的影响  

Effects of Sevoflurane on Woman Baroreflex Sensitivity

作　　者：刘树春[1,2] 刘兴敏[3] 

机构地区：[1]贵州省人民医院麻醉科,贵州贵阳550002 [2]贵阳医学院附院 [3]贵阳医学院附院麻醉科,贵州贵阳550004

出　　处：《贵阳医学院学报》2011年第3期273-275,279,共4页Journal of Guiyang Medical College

摘　　要：目的:研究吸入不同浓度七氟烷对中青年女性患者压力反射敏感性(BRS)的影响。方法:将择期行腰椎、腰椎间盘或下肢骨科手术的女性患者24例随机分成4组(n=6),对照组、0.7最低肺泡有效浓度(MAC)组、1.0MAC组及1.3MAC组;分别于麻醉诱导前和达到预定MAC平稳后测定4组患者的心率(HR)、收缩压(SBP)、平均动脉压(MAP)及基础代谢率(BRS)。结果:1.0MAC组与对照组及0.7MAC组相比,SBP、MAP明显降低(P<0.05),BRS明显降低,P<0.01;与对照组、0.7MAC组、1.0MAC组相比,1.3MAC组的SBP、MAP明显降低(P<0.05),BRS明显降低(P<0.01)。结论:1.0MAC与1.3MAC七氟烷抑制SBP及MAP,七氟烷引起的心率变化与BRS受抑制有关。Objective：To study the effects of different concentrations of sevoflurane by inhaling on baroreflex sensitivity（BRS） of female patients.Methods：Twenty-four female patients accepting operation on lumbar spine,lumbar intervertebral disc or bones of lower limbs were randomly divided into 4 groups（n=6）：control group,0.7MAC group,1MAC group and 1.3MAC group according to the end expiration concentrations of sevoflurane using MAC as unit.HR,SBP,MAP and BRS were detected before anesthesia induction and after reaching of a stable scheduled MAC status in sevoflurane groups.Results：SBP and MAP in 1MAC group were significantly lower than those in control group and 0.7MAC group（P0.05）;SBP and MAP in 1.3MAC group were significantly lower than those in control group,0.7MAC and 1MAC groups（P0.05）;BRS in 1MAC group were significantly lower than those in control group and 0.7MAC group（P0.01）;BRS in 1.3MAC group was significantly lower than those in control group,0.7MAC group and 1MAC group（P0.05）.Conclusions：1.3MAC and 1MAC sevoflurane could depress SBP and MAP.The change of HR caused by sevoflurane may relate to inhibition of BRS.

关 键 词：七氟烷 压力反射敏感性 麻醉 吸入 

分 类 号：R614.21[医药卫生—麻醉学]