血清胱抑素C监测2型糖尿病早期肾损害的Meta分析  

Meta-analysis of value of serum cystatin C in evaluating early kidney dysfunction in diabetes

作　　者：黄玉宇[1] 王衍慧[1] 李静[1] 黄萍[1] 

机构地区：[1]广州市第一人民医院老年内分泌肾内科,广东广州510180

出　　处：《热带医学杂志》2011年第6期676-678,共3页Journal of Tropical Medicine

摘　　要：目的系统评价利用血清胱抑素C与尿微量白蛋白监测2型糖尿病早期肾损害的作用,探讨临床监测2型糖尿病肾功能的最佳手段。方法通过数据库检索国内相关文献,选择评价纳入研究的方法学和提取有效数据后,按Corhrane协作网提供的Meta分析对其进行定量综合分析。结果共有15篇文献纳入标准,2型糖尿病早期血清胱抑素C异常检出率高于尿微量白蛋白,合并OR值为1.95,95%CI为(1.39,2.75)。结论血清胱抑素C是评价2型糖尿病肾功能的灵敏指标,且稳定性好,有利于肾功能损害的早期筛查。Objective To assess the monitor value of serum cystatin C （CysC） and microalbuminuria （mALB） in early stage diabetic nephropathy. Method Systematic review of various data bases was performed in this study, based on Meta-analysis provided by Cochrane Cooperation Network. Results A total of 852 patients were chosen from 15 literatures met the inclusion criteria. Meta-analysis showed the positive ratio of CysC was significantly higher than that of mALB ,with pooled OR 1.92, 95% CI （ 1.39, 2.75）. Conclusion Serum CysC is a sensitive index for evaluating early kidney dysfunction in diabetes.

关 键 词：META分析 血清胱抑素C 糖尿病肾病 筛查 

分 类 号：R587.1[医药卫生—内分泌]