SOX9、结缔组织生长因子促进腱骨结合处愈合的生物力学研究  

Biomechanical research of SOX9,CTGF in bone tendon unction healing

作　　者：朱智奇[1] 江建明[1] 冷燕奎[1] 蔡东岭[1] 

机构地区：[1]南方医科大学南方医院脊柱外科,广东广州510515

出　　处：《细胞与分子免疫学杂志》2011年第7期797-798,800,共3页Chinese Journal of Cellular and Molecular Immunology

摘　　要：目的:观察SRY相关高迁移组box基因9(SOX9)及结缔组织生长因子(CTGF)在促进腱骨结合处愈合的生物力学作用。方法:36只成年新西兰大白兔随机分为A、B、C共3组,每组12只。其中A组为SOX9组:使用SOX9注射腱骨结点处;B组为CTGF组:使用CTGF注射腱骨结点处;C组为单纯对照组。三组动物均行动物试验并分别于术后4周、8周及12周行生物力学测定,统计学分析结果。结果:术后4周、12周,A、B组的横截面积均低于C组,组间对比有统计学差异(P<0.05)。术后4周、8周、12周,A、B组的拉断负荷及极限拉应力均高于C组,组间对比有统计学差异(P<0.05)。结论:SOX9以及CTGF组能够促进腱骨结合处的早期愈合,并能够增加其生物力学强度。AIM：To investigate the biomechanical effect of SOX9,CTGF in bone tendon junction healing.METHODS：36 adult New Zealand rabbits were randomly divided into A,B and C groups（each group were 12 rabbits）.Group A with SOX9 inject into bone tendon junction;Group B with CTGF inject into bone tendon junction;C group was inject nothing.The animal of three groups were used surgery and all of the animals were faced with biomechanical test after 4 weeks,8 weeks and 12 weeks;The result were used statistical analysis.RESULTS：group A and group B＇s cross-sectional area were lower than group C during 4 weeks,12 weeks postoperative;there were statistical difference between each groups（P0.05）.group A and group B＇s pulled off load and ultimate tensile stress were higher than group C during 4 weeks,8 weeks,12 weeks postoperative,the result were statistical difference between each groups（P0.05）.CONCLUSION：SOX9 and CTGF group can not only promote the early bone tendon junction healing,But also increased the biomechanical strength of bone tendon junction.

关 键 词：SOX9 CTGF 腱骨结合处 

分 类 号：R684.7[医药卫生—骨科学]