327例新疆地区IgA肾病病理资料回顾性分析  

The Pathological Data Analysis on 327 Patients with IgA Nephrology in Xinjiang.

作　　者：陆晨[1] 姜鸿[1] 岳华[1] 姬佳妮[1] 徐世茹[1] 何卫[1] 热孜万.阿不都拉 宋雪[1] 阿迪拉.阿布里孜 杨淑芬[1] 侯丽娜[1] 赛福丁.木沙 穆歌[1] 徐钢[2] 刘晓城[2] 

机构地区：[1]新疆维吾尔自治区人民医院,830001 [2]华中科技大学同济医学院附属同济医院,武汉430074

出　　处：《医学研究杂志》2011年第7期33-36,共4页Journal of Medical Research

基　　金：科技部"科技支疆"项目(200840102-38);新疆维吾尔自治区科技攻关课题(200933121)

摘　　要：目的回顾性分析新疆地区不同民族IgA肾病病理、免疫病理及超微结构特点。方法以肾活检确定IgA肾病的检出率、病理类型、病理分级、免疫球蛋白沉积的种类和方式以及超微结构等特点,将亚组资料进行比对及回顾性分析。结果本组中汉族、维吾尔族和其他少数民族的检出率分别为20.06%、27.27%和25.13%;病理类型以系膜增生性肾小球肾炎为主(141例43.12%),其次为轻微病变性肾小球肾炎(53例16.21%)、局灶节段硬化性肾小球肾炎(50例15.29%),膜增生性肾小球肾炎最少(2例0.61%);病理分级集中在Ⅱ和Ⅲ级;免疫球蛋白沉积种类以复合型沉积为主。结论本组资料中IgA肾病病理类型、病理分级以及免疫球蛋白沉积的种类和方式等要素与种族关系不大,但检出率和超微结构显示出因种族的不同而不同,反映出新疆地区IgA肾病独特病理学特点。Objective To analyze the kidney pathology, immuno - pathology and uhra - structure of IgAN patients who were different nationalities in Xinjiang region. Methods Renal biopsy was adopted to make sure the features of IgAN, such as relevance ratio, pathologic type, pathological grade, immune globulin type and pattern and ultra - structure. Then we contrasted and analyzed the subgroup data retrospectively. Results In this group, the relevance ratios of Han majority, Uygur people and other nationalities were 20.06% , 27.27% and 25. 13% respectively. Mesangial proliferative glomerulonephritis （ 141 cases accounting for 43. 12% ） was the uppermost pathologic type followed successively by minor glomerular abnormalities （53 cases accounting for 16.21% ） , focal segmental glomerulo- sclerosis （50 cases accounting for 15.29% ） and membrano - proliferative glomerulonephritis （2 cases accounting for 0.61% ）. The pathological grade focused on class Ⅱ and Ⅲ. The immune globulin type mainly was mixed deposition. Conclusion IgAN factors, such as pathologic type, pathological grade and immune globulin type and pattern, do not relate to the race. However, the relevance ratio and ultra - structure vary by race, reflecting the unique pathological feature of IgA nephropathy in Xinjiang region.

关 键 词：IGA肾病 病理类型 免疫球蛋白 超微结构 

分 类 号：R692.31[医药卫生—泌尿科学]