果蝇DNA甲基化研究进展  

DNA methylation in Drosophila,a review of recent studies

作　　者：郭欣欣[1] 叶海燕[1] 张敏[1] 

机构地区：[1]陕西师范大学生命科学学院,西安710062

出　　处：《遗传》2011年第7期713-719,共7页Hereditas（Beijing)

基　　金：中央高校基本科研业务费专项资金(编号:GK201002042);陕西省自然科学基金项目(编号:2007C101)资助

摘　　要：DNA甲基化是表观遗传调控的重要机制,但果蝇很久以来被认为是一种缺乏甲基化的模式生物。近年来才证实果蝇基因组中有5′-甲基胞嘧啶残基的存在,其DNA甲基化水平在胚胎发育早期达到最高,总体水平低于脊椎动物及植物。果蝇拥有一个包含dDNMT2和dMBD2/3的简单甲基化修饰系统,其分别与哺乳动物中的DNMT2家族及MBD2/MBD3蛋白高度同源。果蝇DNA甲基化模式和特点可能随果蝇种类不同而不同。文章对果蝇DNA甲基化特点及其功能研究进展进行了综述。DNA methylation is a key mechanism underlying epigenetic regulation.Fruit fly has been considered as a free DNA methylation organism until recently a few studies demonstrated that genomic methylated DNA is prevalent during the early embryonic development;but the overall methylation level in Drosophila is lower than in vertebrates and plants.The putative genomic DNA methylation systerm in Drosophila contains a methyltransferase termed dDNMT2 and a methyl-binding protein dMBD2/3.dDNMT2 shows significant homology to the mammalian methyltransferases DNMT2 family,and dMBD2/3 encodes a protein with distinct homology to mammalian methyl-binding proteins MBD2 and MBD3.Some studies also indicated that methylation pattern varies among different species of Drosophila.This article summarizes the recent progresses in studies of DNA methylation in Drosophila.

关 键 词：DNA甲基化 果蝇 甲基化修饰系统 DNA甲基转移酶 

分 类 号：Q963[生物学—昆虫学]