呼吸机相关性肺炎嗜麦芽窄食单胞菌感染的耐药性分析  

Analysis of Drug Resistance of Stenotrophomonas Maltophilia in Newborn with Ventilator Associated Pneumonia

作　　者：欧阳颖[1] 方建培[1] 罗玲[2] 苏浩彬[1] 麦友刚[1] 

机构地区：[1]中山大学孙逸仙纪念医院儿科,510120 [2]中山大学孙逸仙纪念医院检验科,510120

出　　处：《岭南急诊医学杂志》2011年第3期166-167,169,共3页Lingnan Journal of Emergency Medicine

摘　　要：目的:了解新生儿重症监护室(NICU)内呼吸机相关性肺炎(VAP)中嗜麦芽窄食单胞菌(SMA)感染的耐药情况,为指导临床合理用药提供依据。方法:采用MicroscanWalkAway 40全自动微生物分析仪进行细菌鉴定和药敏实验,对气管插管末端或吸痰管末端分离培养的16株SMA的耐药性进行监测。结果:SMA对亚胺培南、头孢曲松、头孢噻肟、庆大霉素的耐药率均在100%,左氧氟沙星、米诺环素、复方新诺明的耐药率(0%-18.7%)最低,替卡西林/棒酸耐药率较低(25%)。结论:SMA为NICU内感染常见菌,耐药率高且易出现多重耐药,应根据药敏结果选取合适的抗生素。Objective： To study the drug resistance of stenotrophomonas maltophilia （SMA） in newborn with ventilator associated pneumonia（VAP）. Methods： 16 SMA trains were isolated from 16 newborns infected with SMA. API staphsystem and K-B agar diffusion method were used to identify the isolated SMA and to perform drug susceptibility testing. Results： 16 SMA trains were isolated.The drug-resistant rate to Imipeuem,Ceftriaxone, Cefotaxime and Gentamycin was 100%,and the rate to levofloxacin,minocycline, compound sulfame-thoxazole was low （0%-18.7%）, relatively low to ticarcillin/ca （25% ）. Conclusion： SMA has become important pathogen of VAP in NICU. The case of the antibiotic-resistant of SMA was serious. Drugs should be chosen based on sensitivity test results in clinical anti-infective therapy.

关 键 词：嗜麦芽窄食单胞菌 耐药性 呼吸机相关性肺炎 

分 类 号：R446.5[医药卫生—诊断学]