3项指标联合检测对糖尿病肾病的早期诊断价值  

The early diagnostic value of combined detection of three markers on diabetic nephropathy

作　　者：王政[1] 

机构地区：[1]浙江省台州市第一人民医院检验科,318020

出　　处：《检验医学与临床》2011年第14期1711-1712,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨联合检测尿转铁蛋白(TRF)、N-乙烯-β-D-氨基葡萄糖苷酶(NAG)及血半胱氨酸蛋白酶抑制剂C(Cys C)对糖尿病肾病的早期诊断价值。方法用免疫比浊法检测尿TRF和血Cys C,终点法检测尿NAG,并比较其在各组中的差异。结果 TRF、NAG及血Cys C在糖尿病无蛋白尿组(A组)中的浓度分别为(3.12±0.45)mg/L(、2.26±0.97)U/mmoL和(1.83±0.37)mg/L,糖尿病蛋白尿组(B组)中的浓度分别为(10.66±3.50)mg/L(、4.30±1.74)U/mmoL和(3.14±0.96)mg/L,A组中各指标的浓度均显著高于健康对照组中相应的浓度,B组中各指标的浓度均显著高于A组中相应的浓度(P<0.05)。单纯检测一项或两项指标阳性率较低,而联合检测则能提高阳性率。结论联合检测尿TRF、NAG及血Cys C能反映糖尿病肾病的早期损害,对糖尿病的早诊断、早治疗有重要的临床价值。Objective To explore the value of combined detection of urinary TRF,NAG and serum cystatin C in the early diagnosis of diabetic nephropathy.Methods The levels of urinary TRF and serum cystatin C were determined by immunity scatting turbidimetry,NAG was determined by endpoint method,then we compared the differences between the various groups.Results The levels of urinary TRF,NAG and serum cystatin C in group A were（3.12±0.45）mg/L,（2.26±0.97）U/mmoL,and（1.83±0.37）mg/L,their levels in group B were（10.66±3.50）mg/L,（4.30±1.74）U/mmoL and（3.14±0.96）mg/L.These various indicators of group A were significantly higher than those of the control group,and these various indicators of group B were significantly higher than those of group A（P0.05）.Positive rates of measuring one or two of the three markers were lower than those of measuring the three markers together.Conclusion Detection of urinary TRF,NAG and serum cystatin C can react early damage in diabetic nephropathy,and it is important for diabetes early diagnosis and early treatment.

关 键 词：转铁蛋白 N-乙烯-β-D-氨基葡萄糖苷酶 半胱氨酸蛋白酶抑制剂C 糖尿病肾病 

分 类 号：R587.104[医药卫生—内分泌]