肝X受体激动剂猪去氧胆酸二甲酰胺抗疲劳作用研究  

The study of anti-fatigue action of LXR agonist hyodeoxycholic acid dimethyl amide on exhaustive mice

作　　者：余昊[1] 于明琦[1] 宋青[1] 

机构地区：[1]北京科技大学化学与生物工程学院,100083

出　　处：《中国现代医药杂志》2011年第7期1-2,共2页Modern Medicine Journal of China

基　　金：2009年北京市教委共建项目

摘　　要：目的探讨肝X受体(LXR)激动剂猪去氧胆酸二甲酰胺的抗疲劳作用,推测人参活性成分抗疲劳作用靶点。方法采用ApoE基因单敲除小鼠和昆明白小鼠两种不同品系小鼠,实验组通过口服连续给予实验药物猪去氧胆酸二甲酰胺4周,剂量为200mg·kg-1·d-1,再分别进行跑步耐力和游泳力竭实验,采集实验组和对照组的运动时间数据。结果 LXR激动剂猪去氧胆酸二甲酰胺(200mg·kg-1·d-1)可以提高ApoE基因单敲除小鼠的跑步耐力、延长昆明白小鼠的游泳时间。结论猪去氧胆酸二甲酰胺具有一定的抗疲劳作用,LXR可能是人参皂苷作用靶点之一。Objective To study anti-fatique effect of a Liver X Receptor（LXR） agonist hyodeoxycholic dimethyl amide（HDCA）;identidy ginseng pharmacological targets.Methods ApoE gene single knock-out mice and Kunming mice were tested on a motor-controlled running wheel or by exhaustive swimming,following oral administration of HDCA at 200mg/kg body weight dose for up to 4 consecutive weeks.Running or swimming time was collected and compared between control and drugtreated animals.Results The result showed that LXR agonist HDCA（200mg·kg-1·d-1） could increase the running time of ApoE single-knockout mice and swimming time of Kunming mice.Conclusion HDCA has anti-fatigue property.LXR may be one of the pharmacological targets of ginsenosides.

关 键 词：LXR 人参皂苷 抗疲劳 小鼠 

分 类 号：R965[医药卫生—药理学]