大麻素受体和配体对胃肠运动及分泌的影响  

Effects of cannabinoid receptors and their ligands on gastrointestinal motility and secretion

作　　者：曹明华[1] 李永渝[1] 

机构地区：[1]同济大学医学院病理生理教研室,同济大学消化系疾病研究所,上海200092

出　　处：《国际外科学杂志》2011年第7期468-471,共4页International Journal of Surgery

基　　金：国家自然科学基金资助项目（No.30971168）

摘　　要：内源性大麻素系统有几种受体，在体内均存在相应的配体和特定的合成及代谢通路，均属G蛋白耦联超家族成员。近来的一些研究显示，大麻素受体激活后可影响胃肠运动及分泌。本文介绍大麻素的种类，其受体、配体、拮抗剂以及它们对胃肠运动和胃肠分泌的影响，为进一步研究内源性大麻素系统对胃肠运动及分泌的作用机制提供资料，并为临床应用该类药物提供理论依据。Endocannabinoid system has several kinds of receptors, all of which have correspondence ligands and pathways of synthesis and degradation, and they belong to G-protein coupled receptors family. Recently studies show that stimulation of eannabinoid receptors has inhibitory effects on gastrointestinal motility and secretion. In this article, we introduce the compositions of the cannabinoid family members, including their receptors, ligands, and antagonists, and their effects on the gastrointestinal motility and secretion. Useful information can be provided for the further study on the effects of endocannabinoid system on gastrointestinal motility and secretion, providing theoretic evidences for clinical use of cannabinoid.

关 键 词：大麻素受体 内源性大麻素系统 胃肠运动 胃肠分泌 

分 类 号：R285.5[医药卫生—中药学]