阿托伐他汀对高血压患者肾损害的影响  

The effect of atorvastatin in hypertensive patient with renal damage

作　　者：王五保[1] 

机构地区：[1]河南省获嘉县人民医院,453800

出　　处：《临床合理用药杂志》2011年第15期17-18,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨阿托伐他汀对高血压患者肾损害的影响。方法选取血压控制达标的高血压并伴微量白蛋白尿患者80例,随机分为治疗组和对照组,每组40例。治疗组予以阿托伐他汀20mg/d,对照组加用安慰剂治疗。2组治疗前及治疗后12周采用速率散射比浊法检测尿微量白蛋白(mAlb)、β2-微球蛋白(β2-MG),采用全定量酶免疫法测定尿视黄醇结合蛋白(RBP),采用速率法检测N-乙酰-β2-D氨基葡萄糖苷酶(NAG),采用Jaffe速率法测定尿肌酐(Cr)。结果治疗组治疗后RBP/Cr、mAlb/Cr、β2-MG/Cr及NAG/Cr水平均降低(P<0.01);且治疗后治疗组上述指标均低于对照组,差异均有统计学意义(P<0.01)。且不良反应轻微。结论阿托伐他汀能减轻高血压患者肾损害症状,并能有效改善其肾功能。Objective To investigate the effect of atorvastatin in hypertensive patient with renal damage.Methods Select target blood pressure control high blood pressure and microalbuminuria in patients with 80 cases,were randomly divided into treatment group and control group,each of 40 cases.Treatment group were given atorvastatin 20mg/d,control group received placebo treatment.Before treatment and 12 weeks after treatment using rate nephelometry assay urinary albumin（mAlb）,β2-microglobulin（β2-MG）,quantitative determination of urinary enzyme immunoassay of retinol-binding protein（RBP）,the rate detection N-acetyl-β-D-glucosaminidase（NAG）,used Jaffe rate method determined urinary creatinine（Cr）.Results After treatment,the levels of RBP/Cr,mAlb/Cr,β2-MG/Cr and NAG/Cr of treatment group were lower（P〈0.01）;And those indicators of treatment group were lower than those of control group,the difference were statistically significant（P〈0.01）.And adverse reactions were mild.Conclusion Atorvastatin can reduce renal damage in patients with hypertension and improve renal function.

关 键 词：阿托伐他汀 高血压 微量白蛋白 Β2-微球蛋白 视黄醇结合蛋白 N-乙酰-β2-D氨基葡萄糖苷酶 

分 类 号：R544.1[医药卫生—心血管疾病]