生长抑素与代谢综合征相关生化及抗氧化指标的关系  

Analysis of correlation between serum somatostatin levels, antioxidant index and metabolic syndrome

作　　者：杨瑞丽[1] 李武[1] 施用晖[1] 乐国伟[1] 

机构地区：[1]江南大学食品学院食品科学与技术国家重点实验室,无锡214122

出　　处：《卫生研究》2011年第4期466-467,471,共3页Journal of Hygiene Research

基　　金：国家自然科学基金项目(No.30571347)

摘　　要：目的探讨生长抑素与代谢综合征相关生化及抗氧化指标的关系。方法测定代谢综合征、代谢综合征高危人群以及正常人群的血清生长抑素(SS)水平、抗氧化相关指标。结果 (1)代谢综合征和高危组SS水平均显著低于正常组。(2)代谢综合征和高危组血清超氧化物歧化酶、谷胱苷肽过氧化物酶水平显著低于正常组,MDA水平显著高于正常组。(3)血清SS水平与AI(r=-0.24,P<0.01)、HOMA-IR(r=-0.23,P<0.05)、MDA(r=-0.25,P<0.01)水平呈负相关。结论机体糖、脂代谢紊乱代谢综合征及高危人群SS水平显著降低,氧化应激程度增加。Objective To investigate serum somatostatin levels,antioxidant index in metabolic syndrome（MS）.Methods Serum somatostatin levels,glucose,lipid level and certain antioxidant indexes were measured in the serum of 39 patients with MS,60 MS high risk subjects（MSR） and 41 normal controls（NC）.The associations of somatostatin with atherosclerotic index（AI）,HOMA-IR and malondialdehyde（MDA） were analyzed.Results（1） Median somatostatin levels were lower in subjects with MS or MSR than in control subjects.（2） The activities of superoxide dismutase（SOD） and glutathione peroxidase（GSH-Px） decreased in subjects with MS or MSR compared with NC（P0.05）.（3） A significant inverse relationships between somatostatin level and AI（r=-0.24,P0.01）,HOMA-IR（r=-0.23,P0.05）,and MDA（r=-0.25,P0.01） were observed.Conclusions The severity of serum glucose and lipid disorders and oxidative stress was accompanied with decreased somatostatin levels.These results suggest a possible role of decreased somatostatin on MS generation.

关 键 词：代谢综合征 生长抑素 氧化应激 

分 类 号：R589[医药卫生—内分泌] Q57[医药卫生—内科学]