基于IEUBK模型研究环境铅对婴儿血铅的影响  

Contribution of environmental lead exposure to blood lead level among infants based on IEUBK model

作　　者：王波[1] 邵迪初 项张华[2] 叶虹[2] 倪为民[3] 杨水莲[3] 吴翠娥[1] 李凭健[1] 傅华[1] 

机构地区：[1]复旦大学公共卫生学院公共卫生安全教育部重点实验室,上海200032 [2]余姚市疾病预防控制中心 [3]上海市杨浦区中心医院

出　　处：《卫生研究》2011年第4期478-480,共3页Journal of Hygiene Research

摘　　要：目的利用环境铅、出生前铅暴露数据和暴露吸收生物动力学模型(IEUBK模型),探讨环境铅对婴儿6月龄时血铅浓度的影响。方法利用2005-2007年的出生队列资料、出生前铅暴露数据和婴儿6月龄时血铅浓度值,以及婴儿居住环境土壤、大气和饮用水等介质中的铅检测数据,基于IEUBK模型计算环境铅引起的婴儿血铅增高水平。结果婴儿出生前就存在铅暴露,孕晚期母亲血铅浓度几何均数为(40.3±3.7)μg/L,6月龄婴儿的血铅浓度的几何均数为(54.7±6.7)μg/L,有17.3%的婴儿血铅浓度超过100μg/L。研究对象居住环境中多种介质均能检测到铅,土壤、大气和饮水中铅的几何均数浓度分别为45.57mg/kg、0.023μg/m3和3.25μg/L。根据IEUBK模型计算的由环境铅及出生前铅暴露引起的婴儿6月龄血铅浓度几何均数值为12.4μg/L,占其实际血铅浓度的22.7%。结论研究区域婴儿仍存在较高水平的血铅暴露,其居住环境内存在一定程度的铅污染现象。除环境铅外,当地婴儿可能还存在其他的铅暴露来源。Objective To evaluate the influence of environmental lead exposure on infant＇s blood lead through integrated exposure uptake biokinetic model for lead in children（IEUBK） model,based on environmental lead and prenatal lead exposure.Methods The data is from a prospective study conducted among pregnant women during 2005-2007.Blood lead of the pregnant women in the late pregnancy,environmental lead values including lead concentration in soil,air and drink-water were measured.Moreover,the blood lead concentrations of infants were measured as well.Results Infants were exposed to lead from the pregnant women during the pregnancy,and in the late pregnancy the geometric mean blood lead of pregnant women was（40.3±3.7）μg/L.The geometric mean blood lead concentration of six-month old infants was（54.7±6.7）μg/L and there were 17.3% infants whose blood lead concentration were above 100μg/L.Lead in soil,atmosphere and drink-water were 45.57mg/kg,0.023μg/m3 and 3.25μg/L respectively.While based on the calculation of the IEUBK model,the value attributed to environmental lead exposure was 12.4μg/L,accounting for 22.7% of the real blood lead level.Conclusion The results indicated that environmental lead contamination in the rural area might not be the main reason of elevation in blood lead among infants,other lead resources such as food lead exposure might be the major sources for the intake of lead among infants and should be paid more attentions in future.

关 键 词：铅 血铅 IEUBK模型 婴儿 环境污染 

分 类 号：R994.6[医药卫生—毒理学]