细胞毒药物与肿瘤血管生成  

Cytotoxic Drugs and Its Anti-angiogenesis

作　　者：屠哲玮[1] 陶一飞 董缙[1] 徐云根[1] 

机构地区：[1]中国药科大学药物化学教研室,南京210009 [2]常州市东吴医药化工技术开发有限公司,江苏常州213026

出　　处：《中国现代应用药学》2011年第7期618-622,共5页Chinese Journal of Modern Applied Pharmacy

基　　金：江苏省高校"青蓝工程"资助项目(2008);江苏省自然科学基金项目(BK2010436)

摘　　要：细胞毒药物在传统抗肿瘤化疗中运用较多,然而由于高剂量的使用难免会引起毒副作用和耐药性。为了使细胞毒药物能安全有效地治疗肿瘤,近年来,人们研究了合理运用细胞毒药物的方法,使其作用从直接杀死肿瘤细胞转变为针对肿瘤血管生成。本文就近十年来在该方面的研究作一综述。Cytotoxic drugs are widely used in traditional antitumor chemotherapy, while the using of high dose will inevitably cause serious side effects and drug resistance. For many years, in order to make cytotoxic drugs be used safely and effectively, researchers have investigated the rational use of cytotoxic drugs, which can turn the mode of action of these drugs from killing tumor cells directly to inhibiting tumor angiogenesis. This article surveys the advances in the rational use of cytotoxic drugs.

关 键 词：细胞毒药物 合理应用 血管生成抑制 节律疗法 

分 类 号：R979.1[医药卫生—药品]