新型含1H-吲唑环的α-氨基膦酸酯的合成及表征  

Synthesis and Characterization of New α-Aminophosphonates Containing 1H-Indazole Moiety

作　　者：武现丽[1] 魏成事[1] 朱春风[1] 吕志丹[1] 廖新成[1] 

机构地区：[1]郑州大学化学系,郑州450052

出　　处：《有机化学》2011年第7期1011-1019,共9页Chinese Journal of Organic Chemistry

摘　　要：以乙二醇为溶剂,邻氟苯丙酮与水合肼环化生成3-乙基-1-H-吲唑(1),进一步经硝化、还原在吲唑环5位引入氨基得到3-乙基-5-氨基1-H-吲唑(3),化合物3与芳香醛的缩合产物席夫碱4a～4k可与亚磷酸酯5m或5n发生进一步亲核加成制得一系列新型5-氨基-3-乙基-1H-吲唑的α-氨基膦酸酯类衍生物6ma～6mk与6na～6nk,所得新化合物均经1H NMR,13C NMR,31P NMR,IR,MS和HRMS确证结构.A series of novel 1H-indazole derivatives 6ma--6mk and 6na-6nk were synthesized via the nucleophilic addition reaction of phosphate esters 5m or 5n with Schiff bases 4a--4k, which were synthesized from nitration, reduction and condensation of aromatic aldehyde by using the 3-ethyl-1H-indazole （1） as starting material. The structures of new compounds were characterized by 1H NMR, 13C NMR, 31p NMR, IR, MS and HRMS spectra.

关 键 词：a-氨基膦酸酯 1H-吲唑 合成 

分 类 号：O627.51[理学—有机化学]