氟氯西林钠多晶型非等温热分解动力学  

Thermal decomposition and non-isothermal kinetics of polymorphs of flucloxacillin sodium

作　　者：周肖寅[1] 刘峥[1] 王苗苗[1] 冯小珍 

机构地区：[1]桂林理工大学化学与生物工程学院,桂林541004 [2]桂林南药股份有限公司,桂林541004

出　　处：《中国新药杂志》2011年第14期1351-1356,共6页Chinese Journal of New Drugs

摘　　要：目的:分析固体氟氯西林钠不同晶型的热分解过程。方法:采用TG-DTG技术研究氟氯西林钠不同晶型在动态氮气气氛中的热分解情况。综合运用微分Achar和积分Coats-Redfern两种热分析动力学方法来处理非等温热分解动力学数据。结果:获得各晶型的热分解动力学参数和方程。结论:氟氯西林钠各晶型的热分解动力学参数和热稳定性能存在差异。Objective： To study the thermal decomposition of flucloxacillin sodium.Methods： The thermo-dissociation of flucloxacillin sodium polymorphs was determined by TG-DTG technique in a condition of dynamic nitrogen atmosphere.The non-isothermal kinetic data of the decomposition process were analyzed by means of Achar method and Coats-Redfern method.Results： The kinetic parameters and dynamical equations of the thermal decomposition of various flucloxacillin sodium forms were obtained.Conclusion： There are differences in the kinetic parameters of the thermal decomposition and thermal stability between different forms of flucloxacillin sodium.

关 键 词：氟氯西林钠 热分解动力学 微分Achar法 积分Coats-Redfern法 

分 类 号：R915.11[医药卫生—微生物与生化药学] R978.1[医药卫生—药学]