The Influence of Phacoemulsification on Corneal Endothelia Cells at Varying Blood Glucose Levels  

The Influence of Phacoemulsification on Corneal Endothelial Cells at Varying Blood Glucose Levels

作　　者：RuiMing Yang Xiangyin Sha Mingbing Zeng Yingqian Tan Yu Zheng Feihong Fan 

机构地区：[1]Department of Ophthalmology, the Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510260, China

出　　处：《Eye Science》2011年第2期91-95,共5页眼科学报（英文版）

摘　　要：Purpose:To investigate the influence of phacoemulsification on corneal endothelial cells in diabetes patients and normal controls. Methods:Phacoemulsification and intraocular lens implantation were performed on 75 patients with diabetic cataract (126 eyes) who were divided into two groups: Trial group 1 (Glu≤6 mmol/L); Trial group 2 (Glu 6-10 mmol/L) and 65 nondiabetic controls (112 eyes).The density and percentage of hexagonal cells and coefficient of variation of the corneal endothelia were measured before surgery and 1 day,1 month and 3 months postoperatively. Results: There was no statistical difference in the density and percentage of hexagonal cells and coefficient of variation of the corneal endothelia prior to phacoemulsification.(P>0.05) between the three groups.The density and percentage of hexagonal cells of the corneal endothelia decreased significantly after surgery in all three groups(P<0.05),while the Coefficient of variation increased in all groups(P<0.05). The rate of loss of corneal endothelial cells in the diabetic groups was significantly higher than for the control group (P<0.05), the percentage of hexagonal cells in the diabetic groups was significantly lower than for the control group (P<0.05), and the coefficient of variation in the diabetic groups was significantly higher than for the control group (P<0.05) at 1 day, 1 month and 3 months post-operatively. There was no statistical difference between the two diabetic groups in terms of these post-operative measurements. Conclusion:The corneal endothelium of diabetic patients is more prone to damage from phacoemulsification. It is advisable to evaluate the corneal endothelium routinely prior to phacoemulsification, particularly in diabetic persons.Purpose： To investigate the influence of phacoemulsification on corneal endothelial cells in diabetes patients and normal controls. Methods： Phacoemulsification and intraocular lens implantation were performed on 75 patients with diabetic cataract （126 eyes） who were divided into two groups： Trial group 1 （Glu≤6 mmol/L） ; Trial group 2 （Glu 6-10 mmol/L） and 65 non-diabetic controls （112 eyes）. The density and percentage of hexagonal ceils and coefficient of variation of the corneal endothelia were measured before surgery and 1 day, 1 month and 3 months postoperatively. Results： There was no statistical difference in the density and percentage of hexagonal cells the corneal endothelia prior to and coefficient of variation of phacoemulsification （P〉0.05） between the three groups. The density and percentage of hexagonal cells of the corneal endothelia decreased signifi cantly after surgery in all three groups（P〈0.05）, while the Coefficient of variation increased in all groups（P〈0.05）. The rate of loss of corneal endothelial cells in the diabetic groups was significantly higher than for the control group （P〈0.05）, the percentage of hexagonal cells in the diabetic groups was significantly lower 6han for the control group （P〈0.05）, and the coefficient of variation in the diabetic groups was significantly higher than for the control group （P〈0.05） at 1 day, 1 month and 3 months post-operatively. There was no statistical difference between the two diabetic groups in terms of these post-operative measurements. Conclusion： The corneal endothelium of diabetic patients is more prone to damage from phacoemulsification. It is advisable to evaluate the corneal endothelium routinely prior to phacoemulsification, particularly in diabetic persons.

关 键 词：角膜内皮细胞 超声乳化 白内障 血糖水平 糖尿病人 变异系数 对照组 六角形 

分 类 号：S886.9[农业科学—特种经济动物饲养] TS959.6[农业科学—畜牧兽医]