血浆纤维蛋白原与冠心病患者胆固醇、血液流变学的相关性及药物干预的研究  

RELATIONSHIP BETWEEN FIBRINOGEN AND CHOLESTEROL AND HEMORRHEOLOGY IN CORONARY HEART DISEASE AND ITS CHANGE AFTER MEDICAL TREATMENT

作　　者：王梦义[1] 张宏[1] 韩金霞[1] 王珺[1] 李淑珍 

机构地区：[1]天津医科大学第二医院内科

出　　处：《天津医科大学学报》1999年第3期32-34,共3页Journal of Tianjin Medical University

摘　　要：目的：研究血浆纤维蛋白原（ｆｉｂｒｉｎｏｇｅｎ，ＦＧ）与冠心病（ＣＨＤ）患者胆固醇、血液流变学的相关性及腹蛇抗栓酶（ＡＨＶＡＴ）的治疗效果。方法：观察６６ 例ＣＨＤ 患者血浆ＦＧ、胆固醇（ＣＨＯ）及血浆粘度、低切变血粘度、红细胞聚集指数等血液流变学指标与６０ 例正常人对照。将６６例ＣＨＤ患者随机分为ＡＨＶＡＴ治疗组３２ 例及肝素治疗组３４ 例，观察治疗前后上述指标的变化。结果：ＣＨＤ组血浆ＦＧ、ＣＨＯ、血浆粘度、低切变血粘度、红细胞聚集指数均明显高于正常对照组（Ｐ＜ ０．０１）。ＣＨＤ组患者血浆ＦＧ 水平与ＣＨＯ、血浆粘度、低切变血粘度、红细胞聚集指数呈直线相关（Ｐ＜ ０．０５， Ｐ＜ ０．０１）。用ＡＨＶＡＴ治疗后上述指标明显下降（Ｐ＜ ０．０５）。结论：血浆ＦＧ 升高与ＣＨＯ 升高有关，血浆ＦＧ 升高可导致ＣＨＤ患者血浆粘度、低切变血粘度及红细胞聚集指数的升高，用ＡＨＶＡＴ 治疗可降低ＣＨＤ患者血浆ＦＧ及ＣＨＯ水平。Objective: To investigate the effect of plasma fibrinogen( FG) on viscosity of coronary heart disease(CHD), and the treatment effect of agkistrodon halys venin antithromboticases(AHVAT) on CHD. Methods: The levels of plasma FG, cholesterol(CHO), and the index of blood viscosity were measured in 66 cases of CHD patients and 60 normal subjects (controls). 66 cases of CHD were randomly assigned to AHVAT treatment group ( n =32) and heparin treatment group( n =34), and were examined again with above index after treatment. Results: Plasma FG and CHO levels of CHD patients were significantly higher than control group ( P <0.01). In CHD group, the levels of FG correlated with CHO, plasma viscosity, blood viscosity in low shear rate and the index of red cell aggregation( P<0.05,P <0.01); the index above were obviosly decrease after treatment with AHVAT ( P <0.05). Conclusion : Fibrinogenemia can markedly elevate the plasma viscosity, low shear rate blood viscosity and the index of red cell aggregation. AHVAT can decrease the levels of FG, CHO of CHD patients, and reduce multiple index of hemorrheology.

关 键 词：纤维蛋白原 冠心病 胆固醇 血液流变 腹蛇抗栓酶 

分 类 号：R541.4[医药卫生—心血管疾病]