^18F-FLT PET显像预测肿瘤增殖的临床研究进展  

Clinical progress of measuring tumor cell proliferation with ^18F-FLT PET

作　　者：陈忠杰[1] 于金明[2] 

机构地区：[1]天津医科大学附属肿瘤医院天津市肿瘤防治重点实验室,300060 [2]山东省肿瘤防治研究院放疗科

出　　处：《国际肿瘤学杂志》2011年第7期499-502,共4页Journal of International Oncology

摘　　要：3′-脱氧-3′-^18F-氟代胸苷（^18F-FLT）被认为是反映肿瘤细胞增殖的新的正电子发射断层显像（PET）示踪剂。越来越多的临床研究显示，^18F-FLT PET显像能够预测肿瘤在治疗过程中的增殖变化，能够早期发现肿瘤再增殖，能够在肿瘤体积缩小前预测残存病灶的位置和活性，并且能够根据治疗过程中肿瘤变化情况预NIle瘤的复发率和远期生存。3＇-deoxy-3＇-^18 F-fluorothymidine has been described recently as a new positron emission tomography （PET） tracer for imaging tumor cell proliferation. In recent years, more and more clinical research demonstrate that ^18F-FLT can image tumor cell proliferation during treatment, and can reflect accelerated reproliferation earlier, it can define tumor subvolumes with high proliferative activity preceding volumetric tumor response, and can predict relapse and prognosis according to the changing status during the treatment.

关 键 词：3′-脱氧-3′-^18F-氟代胸苷 肿瘤 细胞增殖 

分 类 号：R817.4[医药卫生—影像医学与核医学]