高通量血液透析联合超纯透析液对尿毒症贫血的影响  

Effect of high-throughput hemodialysis joint ultra pure dialysate in uremia anemia

作　　者：黄志勇[1] 钟家浩[1] 卓建钦[1] 

机构地区：[1]广东省惠州市第一人民医院,516000

出　　处：《中国医学创新》2011年第21期51-52,共2页Medical Innovation of China

摘　　要：目的探讨高通量血液透析联合超纯透析液在尿毒症贫血治疗中的疗效及安全性。方法选取要进行血液透析的患者43例,随机分成高通量透析组和低通量透析组,两组基本情况无显著差异,均使用德国贝朗Diacap超纯滤器在线产生的超纯透析液,高通量透析组使用的透析器为德国Fressenius公司生产的F60高通量透析器[材料为聚砜膜,表面积为1.3 m^2,超率系数为40 ml/(h·mm Hg)],低通量透析组采用同一家公司生产的F60低通量透器[材料为聚砜膜,表面积为1.3 m^2,超滤系数为5.5 ml/(h·mm Hg)];每个月定期上机前取血标本,查血常规、血生化、透析前后血压,观察患者精神状态,注意患者是否有不适症状发生等。通过SPSS 16.0统计软件治疗前和治疗后分析,评价治疗前后各指标变化情况。结果过高通量联合超纯透析液治疗,高通量透析组指标血红蛋白、血清铁蛋白、红细胞比容、血清肌酐、血尿素氮和β_2微球蛋白(mg/L)蛋白在治疗后与低通量透析组差异均有显著性(P<0.05)。结论高通量血液透析联合超纯透析液对于尿毒症贫血的治疗具有积极作用,长期治疗可以改善尿毒症贫血。Objective To investigate high - throughput hemodialysis joint ultra pure dialysate in uremia anemia both safety and efficacy of treatment. Methods Selected hemodialysis patients to 43 cases were randomly divided into high throughput dialysis group and low flux dialysis group, two groups of basic situation, all use no significant differences Diacap ultra pure German BeiLang ultra pure filters online produce dialysate,high - throughput dialysis for the group to use membrane Fressenius company production of German F60 high - throughput membrane [ material for PVC, surface area of 1.3 PSF mem- brane, super rate coefficient for m2 40 ml/（ h -mm Hg） ] , low flux dialysis group adopted the same companies production F60 low flux through device [ material is gathered, surface area of 1.3 PSF membrane, ultrafiltration coefficient for m2 5.5 mU（ h -mm Hg） ] ; Each month, computer regularly take blood samples before routine blood, blood, check of biochemistry, dialysis patients were observed before and after blood pressure, whether patients with mental condition, attention has symp- toms occur, etc. Through the statistical software SPSS 16. 0 before and after treatment treatment before and after treatment, e- valuation analysis of changes each index. Results Too high throughput joint super pure dialysate treatment, high - throughput dialysis group index hemoglobin, serum ferritin, RBC hematocrit, serum ereatinine, blood urea nitrogen and beta 2 micro globulin （rag/L） protein after treatment with low flux dialysis group differences are significant （P 〈 O. 05 ）. Conclusion high - throughput hemodialysis joint ultra pure dialysis treatment for uremia anemia has played an active role, long - term treatment can improve uremia anemia.

关 键 词：高通量血液透析 超纯透析液 尿毒症贫血 

分 类 号：R692.5[医药卫生—泌尿科学]