血清Cystatin C、β_2-MG、UA在兔单侧输尿管部分梗阻性肾病中的意义  

Significance of serum cystatin C、β_2-MG、UA in rabbit kidney with partial unilateral ureteral obstruction

作　　者：朱少杰[1] 任来成[1] 郝志轩[1] 

机构地区：[1]山西医科大学第二医院泌尿外科,太原030001

出　　处：《中国医疗前沿》2011年第11期22-23,共2页China Healthcare Innovation

摘　　要：目的观察兔单侧输尿管部分梗阻(partial unilateral ureteral obstruction,PUUO)后不同时期的血清半胱氨酸蛋白酶抑制剂C(Cystatin C,Cys C)、β2-微球蛋白(β2-microglobulin,β2-MG)、尿酸(Uric Acid,UA)的变化,探讨联合测定血清Cys C、β2-MG、UA在肾积水肾功能损害的诊断、治疗和恢复中的应用价值。方法建立PUUO模型,检测兔血清Cys C、β2-MG、UA。以核素肾动态显像测得的肾小球滤过滤(GFR)为标准,比较Cys C、β2-MG、UA与GFR的相关性。结果 PUUO模型的兔血清Cys C、β2-MG、UA在输尿管部分梗阻后1周与对照组相比差异无统计学意义(P>0.05),梗阻后2周、4周、8周不同时间点均显著高于对照组(P<0.01);血清Cys C、β2-MG、UA与GFR存在着显著相关关系。结论血清Cys C、β2-MG、UA是反映GFR较理想的血清标志物,对肾积水肾功能损害程度的判断具有极其重要的意义,动态观察可用于指导临床上肾积水肾功能损害的诊断、治疗和恢复情况。Objective To investigate the changes of different stages of serum Cystatin C,β2-microglobulin,Uric Acid in rabbits of partial unilateral ureteral obstruction is to explore the value of Cys C,β2-microglobulin,Uric Acid for diagnosing,recoverying and treating renal dysfunction.Methods Cys C,β2-microglobulin,Uric Acid were measured in rabbits of partial unilateral ureteral obstruction.Glomerulaf filtration rate（GFR） by radionuclide renography was considered to be a standard to decide the correlation between GFR and the above three parameters.Results Serum Cys C,β2-microglobulin,Uric Acid levels of the PUUO group in the 1 week in the kidneys of rabbits with the model group and the control group,were no statistical significance（P〈0.05）,and the three parameters＇ levels were significantly increased（comparing the control group,P〈0.01） after 2 weeks,4 weeks,8 weeks in PUUO groups.The correlation between the three parameters and GFR is very significant.Conclusion Serum cys C,β2-microglobulin,Uric Acid are more sensitive makers for GFR,which are more significant in judging the level of the Hydronphrosis,and in diagnosising,treating and recoverying in clinical.

关 键 词：输尿管部分梗阻 半胱氨酸蛋白酶抑制剂C Β2-微球蛋白 尿酸 

分 类 号：R392.7[医药卫生—免疫学]