宫颈癌患者治疗前、后血清同型半胱氨酸浓度变化的研究  

Study on change of serum homocysteine concentration of patients with cervical cancer during pre-and post-treatment

作　　者：刘梦琼[1] 潘虹[1] 王俏梅[1] 何芳[1] 古升[1] 

机构地区：[1]海南省人民医院检验科,海南海口570311

出　　处：《检验医学》2011年第7期436-439,共4页Laboratory Medicine

摘　　要：目的探讨血清同型半胱氨酸(Hcy)浓度在宫颈癌患者治疗前、后的变化与治疗转归的关系。方法采用循环酶法测定86例初治无转移宫颈癌患者治疗前、治疗结束时及治疗后血清Hcy浓度,并随访36个月,观察其变化,分析其与肿瘤转归的关系。结果 86例宫颈癌患者中有43例治疗前血清Hcy浓度高于正常参考范围,治疗结束后3个月有39例(90.69%)Hcy浓度降至正常参考范围。其余43例宫颈癌患者治疗结束时血清Hcy浓度与治疗前相比明显下降(P<0.001),且治疗后3个月Hcy浓度明显低于治疗结束时(P<0.001)。无复发转移的宫颈癌患者在治疗后6～36个月随访期内血清Hcy浓度稳定在相对低位小幅度(<2μmol/L)波动;而出现复发转移者的血清Hcy浓度在治疗后3个月时下降至正常参考范围,在诊断复发转移前约3～6个月又开始回升,在诊断复发转移时升高至治疗前浓度甚至更高,Hcy浓度波动范围均超过3μmol/L。结论宫颈癌患者血清Hcy水平治疗前半数高于正常参考范围,治疗后明显下降;复发转移患者在诊断前3～6个月血清Hcy浓度开始回升。血清Hcy测定对宫颈癌诊断和转归有一定的参考价值。Objective To investigate the relationship between the change of serum homocytsteine（Hcy） concentration during the pre-and post-treatment and the prognosis of patients with cervical cancer.Methods The Hcy concentrations of 86 cervical cancer patients without metastasis were measured by enzymatic circling assay during pre-,the end of and post-treatment with a follow-up of 36 months.The change of Hcy and the relationship between Hcy and prognosis were analyzed.Results The Hcy concentrations of 43 cervical cancer patients during pre-treatment were higher than the normal reference range,and the Hcy concentrations of 39 patients（90.69%） were under the normal reference range after the treatment for 3 months.The Hcy concentrations of the other 43 cervical cancer patients at the end of treatment were lower than those during pre-treatments（P0.001）,and the Hcy concentrations after the treatment for 3 months were significanthy lower than those at the end of trentment（P0.001）.In patients without recurrence and/or metastasis,the concentrations of Hcy were maintained at a relatively low level with a small fluctuation（2 μmol/L）.In patients suffering from recurrence and/or metastasis,the concentrations of Hcy were within the normal reference range after the treatment for 3 months,the concentrations of Hcy increased again during 3-6 months before the diagnosis of recurrence and/or metastasis,and the concentrations of Hcy increased in the diagnosis and were more higher than those during pre-treatment with a fluctuation over 3 μmol/L.Conclusions A half of Hcy concentration was higher than the normal reference range during the pre-treatment.Hcy of patients with cervical cancer would decrease significantly after the treatment,and increases again during 3-6 months before the diagnosis of recurrence and/or metastasis.Hcy as a predictor of the diagnosis and prognosis in patients with cervical cancer is worth to do further study.

关 键 词：同型半胱氨酸 宫颈癌 循环酶法 

分 类 号：R446.1[医药卫生—诊断学]