冠心胶囊对冠心病介入术后患者血清胱抑素C及尿β_2-微球蛋白的影响  

Influence of Guanxin Capsule on Cystain C and Urine β_2-microglobulin in Coronary Heart Disease after Percutaneous Coronary Intervention

作　　者：梁海龙[1] 张敏州[1] 陈秋雄[1] 盛小刚[1] 

机构地区：[1]广东省中医院

出　　处：《中西医结合心脑血管病杂志》2011年第7期774-775,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的观察冠心胶囊对冠心病介入术后患者肾功能指标血清胱抑素C(Cys C)及尿β2-微球蛋白(β2-MG)水平的影响。方法将64例患者随机分为治疗组、对照组,各32例,两组疗程均为7 d,疗程结束后评定疗效。结果治疗组与对照组比较,患者Cys C、尿β2-MG水平在治疗前、介入后48 h无统计学意义(P>0.05);而在介入后7 d,Cys C水平治疗组为(0.86±0.14)g/L明显低于对照组(0.94±0.29)g/L(P<0.01),尿β2-MG水平治疗组为(0.19±0.16)g/L明显低于对照组(0.33±0.27)g/L(P<0.01)。结论冠心胶囊能明显降低Cys C、尿β2-MG含量,有减少碘对比剂急性肾损害的作用。Objective To investigate the effect of Guanxin capsule on cystain C and urine β2-microglobulin（β2-MG） in patients with coronary heart disease after percutaneous coronary intervention（PCI）.Methods Sixty-four patients were randomly divided into two groups：Control group（n=32） treated with routine western medicine therapy,and treatment group（n=32） treated with Guanxin capsule for 7 days.Results After treatment,the level of cystain C and urine β2-MG had no change compared with that before administration in two groups（P0.05）.At 7 days,the level of cystain C and urine β2-MG in treatment group was significantly lower than that in control group（P0.01）.Conclusion Guanxin capsule had effect on contrast-induced acute kidney injury after PCI by reducing the level of cystain C and urine β2-MG.

关 键 词：冠心胶囊 冠状动脉疾病 血清胱抑素C 尿Β2-微球蛋白 介入治疗 对比剂 肾损害 

分 类 号：R541.4[医药卫生—心血管疾病] R289.5[医药卫生—内科学]