无创性肢体缺血预适应对中年大鼠心肌缺血再灌注损伤心率失常及MDA、SOD表达的影响  

作　　者：潘晓栗[1] 王译[1] 

机构地区：[1]山西省临汾职业技术学院,041000

出　　处：《医学信息（下旬刊）》2011年第7期22-22,24,共2页Medical information

摘　　要：目的：研究无创性肢体缺血预适应的对中年大鼠心肌缺血再灌注损伤心率失常的影响，厘对MDA、SOD表述的影响，从而探讨其作用机制，方法：将中年走鼠随机分为3组。对照组（C组）：只对心脏实施冠脉左前降支（LAD）缺血45min／再灌120min（I／R）处理；一天无创缺血预适应组（1E组）：右后肢实施3个循环缺血5min／再灌10min后（RIP）立即对心脏LAD实施I／R处理；三天无创缺血预适应组（3E组）：每天实施RIP3个循环，连续3d后立即对心脏LAD实施I／R处理。对预适应组中年大鼠（鼠龄12—14mon）实施1d或连续3d无创性后肢缺血预适应后分剐对其《脏LAD实施I／R处理，与对照组（单纯实施心脏I／R）相比较，观察无创性肢体缺血预适应对中年大鼠心I／R后血清MDA、SOD、4律失常Lambeth评分的影响．结果；IE组和3E组的心律失常Lambeth评分分别为2．8±0．74和2．8±1．03，显著低于对照组的评分（4．3±0．65），P〈O．05；血清中Malondidehyde（MDA）的舍量减少：IE、3E纽MDA含量分别为（7．46±0．96）nmol／ml、（7．21±0．79）nmol／ml，明显低于对照纽（9．38±0．85）nmol／ml，P〈0．05；SOD醇活性增加：IE、3E组血清中SOD酶活性分别为（279．26±38．59）N／ml、（374．17±42．18）N／ml，与对照组（217．28±42．36）N／ml相比，显著升高（P〈0．05）。结论：无创性后肢缺血预适应可降低血清中MDA含量，增高soD酶活性及降低心律失常评分。Study： for sexual purposes without members to adapt to middle age there＇s a shortage rats out arch--humorist imparts more damage to the myocardium was poorly there＇s a shortage of the heart rate, and the mda, the sod order to explore the role of the mechanism, method ： middle--aged rats will be randomly divided into three groups, The various groups .. only for the implementation of the coronary artery left before the lad there＇s a shortage of 45 min to pour 120 min; i do not create there＇s a shortage in a day to set, right after the amputation of the three loop there＇s a shortage of 5 min to fill up the rip 10rain on the implementation of the lad handled ; r i have three days in advance to （ there＇s a shortage of 3e group ） ： rip3 a cycle of day, after the 3d on the implementation of the lad. Simple, arid the implementation of ther was observed in sex is no physical there＇s a shortage of rats to adapt to the mid- dle of the r i, the mda and sod, arrhythmias score of lambeth, result： le group and 3e of lambeth arrhythmias score of 2.8 ± 0.74 and 2.8 ±1.03, significantly lower than in the rating （4.3 ±0.65）, p 〈0.05 ;Sod enzyme activity, add le 3e group, serum sod enzyme activity is （279.26 ±38.59） n ml, （374.17 ± 42.18） n ml, and the （217.28 ± 42.36） n ml, significantly higher than （p〈0.05）. No conclusion in nature and limb to reduce there＇s a shortage in the mda level in the higher the sod and enzyme activity and lowering grading arrhythmias.

关 键 词：后肢缺血预适应 缺血再灌注损伤 心率失常 MDA SOD 

分 类 号：R542.2[医药卫生—心血管疾病]