EDTA、DTPA与6氨-基青霉烷酸衍生物的合成  

Synthesis of 6-Aminopenicilanic Acid Derivates with EDTA and DTPA

作　　者：马肖依[1] 郝志峰[1] 刘文锋[1] 余坚[1] 

机构地区：[1]广东工业大学轻工化工学院

出　　处：《光谱实验室》2011年第4期1612-1616,共5页Chinese Journal of Spectroscopy Laboratory

基　　金：广东省自然科学基金资助项目(06021469)

摘　　要：乙二胺四乙酸二酐(EDTAD)和二乙三胺五乙酸二酐(DTPAD)分别与6氨-基青霉烷酸(6-APA)反应,合成了两个新的化合物EDTA-6-APA和DTPA-6-APA。通过UV、IR、1H NM R、元素分析对化合物的组成和结构进行了初步表征。探讨了反应物的配比、反应温度、反应时间等反应条件对产物收率的影响。结果表明,最佳合成条件为:n(酸酐)∶n(6-APA)=1∶2,反应温度25℃,反应时间7h,此时产物收率均达到70%以上。The new two complexes,EDTA-6-APA and DTPA-6-APA,were respectively synthesized by reaction of EDTA dianhydride and DTPA dianhydride with 6-aminopenicilanic acid（6-APA）.The compositions and structures of the complexes were characterized by UV,IR,1H NMR and elemental analysis.The effects of reactant proportion,reaction temperature and reacton time on the yield were investigated.The optimized parameters for the synthesis were as follows：the molar ratio of dianhydride to 6-APA was 1∶2,and reaction temperature was 25℃ with reaction time of 7h.The yields of the products were all above 70% under the conditions.

关 键 词：乙二胺四乙酸 二乙三胺五乙酸 6氨-基青霉烷酸 酰化反应 

分 类 号：O657.32[理学—分析化学] O657.2[理学—化学]