钯催化Suzuki偶联反应合成2-(3′-噻吩基)噻唑  

Preparing 2-(thiophen-3-yl)thiazole by Pd-Catalyzed Suzuki Cross-coupling Reactions

作　　者：张罡[1] 苏箐[1] 

机构地区：[1]河南城建学院化学化工系,河南平顶山467001

出　　处：《广东化工》2011年第7期57-58,共2页Guangdong Chemical Industry

摘　　要：以3-噻吩硼酸和2-溴噻唑为原料,以Pd(PPh3)4为催化剂,通过Suzuki偶联反应合成了2-(3′-噻吩基)噻唑,考察了不同的碱,不同的溶剂,不同原料比例和不同催化剂比例对该Suzuki偶联反应产率的影响。结果显示:目标产物收率在溶剂为乙醇,K2CO3为碱,原料比例为1.5∶1的时候最高,且反应时间较短。2-（thiophen-3-yl）thiazole was synthesized via Suzuki coupling reaction of 2-bromothiazole and thiophen-3-ylboronic acid by using Pd（PPh3）4 as catalysts. The influences of different bases, various solvents, and different ratios of raw materials on the reaction were investigated. The .optimum reaction condition was toluene as solvent, K2CO3 as base, the molar ratio of thiophen-3-ylboronic acid and 2-bromothiazole 1.5 ： 1.

关 键 词：钯催化 SUZUKI偶联反应 Pd(PPh3)4 2-溴噻唑 3-噻吩硼酸 

分 类 号：TQ463[化学工程—制药化工]