SOCS3分子——治疗人类多种疾病的潜在靶标  

SOCS3:a potential therapeutic target for many human diseases

作　　者：许文频[1] 李卫东[1] 

机构地区：[1]北京大学医学部基础医学院药理学系,北京100191

出　　处：《药学学报》2011年第7期747-752,共6页Acta Pharmaceutica Sinica

基　　金：北京市自然科学基金资助项目(7102100)

摘　　要：业已发现,多种细胞因子和炎症因子可诱导SOCS3的表达,表明SOCS3在细胞信号转导通路中发挥重要调控作用。经10多年研究,SOCS3分子在人体多种组织的生理功能维持和病理变化进展中的作用已日益明确。本文从近年来研究SOCS3较多的疾病(炎症、病毒感染、肥胖及肿瘤)出发,综述该分子在疾病的发生、发展、诊断和治疗中的作用。在人类多种疾病发生发展中,SOCS3均表现出水平异常或功能发挥异常,提示SOCS3可作为一些疾病诊断及预测预后的生物分子指标,以及特定疾病的治疗靶标。SOCS3 has significant regulation effects in cell signal transduction pathways,which can be induced by many kinds of cytokines and proinflammatory factors.After being studied for years,the effect of SOCS3 has become clear in maintaining physiological functions and affecting histopathologic changes in human tissues.This review presents the role of SOCS3 in the occurrence,development,diagnosis and treatment of human diseases,such as inflammation,virus infection,obesity and tumor.As abnormal levels or impaired function of SOCS3 were reported in the onset and development of disease,SOCS3 can be considered as a bio-marker to diagnose and predict prognosis of some disorders,and as a therapeutic target for certain diseases.

关 键 词：SOCS3 炎症 病毒感染 肥胖 肿瘤 潜在治疗靶标 

分 类 号：R963[医药卫生—微生物与生化药学]