大蒜有机硫化物抗肿瘤机制及应用前景探讨  

The Anti-tumor Mechanism and Application Prospects of Garlic-derived Organosulfur Compounds

作　　者：王颖钰[1] 陆茵[1,2] 钱文慧[1] 赵杨[1] 王生[1] 陶丽[1] 

机构地区：[1]南京中医药大学药学院,江苏南京210029 [2]江苏省方剂重点研究实验室,江苏南京210046

出　　处：《安徽农业科学》2011年第19期11454-11457,共4页Journal of Anhui Agricultural Sciences

基　　金：国家自然科学基金项目资助(30371727;30772766);江苏省自然科学基金项目资助(BK2007239);江苏省教育厅重大专项(09KJA360002);江苏省六大人才高峰课题(06-B-023);江苏省六大人才高峰课题A类第五批项目资助(08-A-012);江苏省中医药局项目(LZ09022);江苏省中药药效与安全性评价重点实验室开放课题(P09013)

摘　　要：大蒜为百合科葱属植物蒜的鳞茎,性温,味辣,其主要生物活性成分为多种有机硫化物(OSCs),具备抗菌消炎、降低胆固醇、抗血小板聚集、抗肿瘤等功效。近年来国内外流行病学调查及试验研究表明,OSCs对多种恶性肿瘤均有明显的抑制作用,其主要作用机制包括预防致癌物质活化、调控细胞内酶系统进行解毒、阻断肿瘤细胞周期、诱导凋亡、抑制转移及抗肿瘤血管生成等。笔者就大蒜有机硫化物(OSCs)抗肿瘤作用机制进行概述,为临床开发低毒高效的抗肿瘤中药提供了依据。Garlic（Allium sativum） is a bulbous root with a strong taste and smell.Garlic has extensive pharmaceutical activities such as antibacterial,hypolipidemic,inhibition of platelet aggregation and antitumor and so on.The anticarcinogenic effect of Allium vegetables including garlic is attributed to its organosulfur compounds（OSCs）.Population-based case control studies have suggested an inverse correlation between dietary intake of Allium vegetables and the risk of different types of cancers.The main functional mechanisms included prevention the activation of carcinogens,induction of Phase 2 enzymes,blocking cell cycle,inducing tumor cell apoptosis,inhibition of tumor metastasis and antiangiogenesis.This paper summarized current knowledge on the antitumor effects of OSCs and provided basis for clinicall developing safe and effective drug against tumor metastasis.

关 键 词：大蒜 有机硫化物 肿瘤 药理作用 应用前景 

分 类 号：S633.4[农业科学—蔬菜学]