N-乙酰基转移酶2基因多态性与染发皮炎易感性关系  

Relationship between polymorphism of arylamine N-acetyltransferase 2 and genetic susceptibility to hair dye dermatitis

作　　者：杨秋艳[1] 徐宏俊[1] 刘原君[1] 姚卫锋[1] 刘全忠[1] 

机构地区：[1]天津医科大学总医院皮肤科,天津300052

出　　处：《中华医学美学美容杂志》2011年第3期190-193,共4页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的 探讨N-乙酰基转移酶2（NAT2）基因多态性与中国人染发皮炎遗传易感性的关系.方法 应用聚合酶链反应（PCR）及限制性片段长度多态性（RFLP）技术检测和分析天津地区60例染发皮炎患者及73例正常对照者的NAT2野生型等位基因（NAT2＊4）和3个常见突变位点（NAT2＊5A,NAT2＊6B和NAT2＊7A）的基因多态性,比较NAT2各等位基因及基因型频率在染发皮炎组与对照组间分布差异.结果 NAT2等位基因NAT2＊4,NAT2＊5A,NAT2＊6B和NAT2＊7A在染发皮炎组中的分布频率分别是52.5%,5.0%,26.7%,15.8%,在对照组中为55.5%,3.4%,27.4%,13.7%,两组相比差异均无统计学意义（P〉0.05）;快型、中间型、慢型基因型在染发皮炎组中频率分别是26.7%,51.7%,21.7%,在对照组中为30.1%,50.7%,19.2%,与对照组相比差异无统计学意义（P〉0.05）.结论 NAT2基因多态性与中国汉族人染发皮炎遗传易感性无关.Objective To investigate the relationship between polymorphism of arylamine N-acetyltransferase 2 （NAT2） and hair dye dermatitis in a Chinese population. Methods Polymorphism chain-restriction fragment length polymorphism （PCR-RFLP） was used and the wild-type allele （NAT2 ＊ 4） and three mutant alleles （NAT2 ＊ 5A, 6B and 7A） were determined in 60 patients with hair dye dermatitis and 73 age-matched control subjects in Tianjin region. Results In hair dye dermatitis cases, the frequency of NAT2 ＊ 4, NAT2 ＊ 5A, NAT2 ＊ 6B, NAT2 ＊ 7A was 52. 5 % , 5. 0 % ,26.7 % and 15. 8 %, respectively, and no statistically significant difference of the frequencies was found between the hair dye dermatitis patients and controls （P〉0. 05）. The frequency of rapid genotype, intermediate genotype and slow genotype was 26. 7 % , 51. 7 % and 21. 7 % in hair dye dermatitis cases, 30. 1 %, 50. 7 % and 19. 2 % in control subjects, respectively, and no statistically significant difference of the frequencies between the two groups （P〉0. 05）. Conclusions Our study suggests that there might be no relationship between polymorphism of NAT2 and genetic susceptibility to hair dye dermatitis in a Chinese population.

关 键 词：染发皮炎 N-乙酰基转移酶2 基因多态性 

分 类 号：R758.22[医药卫生—皮肤病学与性病学]