阻塞性睡眠呼吸暂停综合征患者事件相关电位研究  

Abnormal P3 latency in obstructive sleep apnea syndrome

作　　者：彭斌[1] 李舜伟[1] 黄席珍[2] 汤晓芙[1] 吴全有[2] 罗英[1] 

机构地区：[1]中国医学科学院 [2]呼吸内科睡眠呼吸监测中心

出　　处：《中华神经科杂志》1999年第6期361-364,共4页Chinese Journal of Neurology

摘　　要：目的　研究阻塞性睡眠呼吸暂停患者事件相关电位Ｐ３ 的变化，探讨可能的机制。方法　入组受试者分为阻塞性睡眠呼吸暂停患者组（ｎ ＝ ３０） 及正常对照组（ｎ ＝ ３０） ，均进行睡眠多导仪、听觉诱发事件相关电位（Ｐ３） 、临床记忆量表检查及神经系统查体。结果采用ｔ 检验和Ｓｐｅａｒｍａｎ 等级相关分析。结果　阻塞性睡眠呼吸暂停患者组记忆商（ＭＱ）为９０ ±１２ ，Ｐ３ 潜伏期为（３５９±３０） 毫秒（Ｆｚ 记录点） ，（３６５±３１） 毫秒（Ｃｚ 记录点） ；正常对照组ＭＱ为１０４±１６，Ｐ３ 潜伏期为（３３７±２９） 毫秒（Ｆｚ记录点） ，（３３９±３１）毫秒（Ｃｚ 记录点） 。阻塞性睡眠呼吸暂停患者组与正常对照组的Ｐ３ 潜伏期和记忆商差异存在显著性意义（Ｐ＜ ０．０５）。结论　阻塞性睡眠呼吸暂停患者有认知功能损害，夜间低氧血症可能起重要作用。Objectives To evaluate the P3 latency in patients with obstructive sleep apnea syndrome (OSAS) and investigate the possible mechanism. Method The two groups, consisting of the OSAS patients group ( n =30), and the control group ( n =30), were administered polysomnography (PSG) auditory evoked event related potential (P3) and clinical memory test. The results were analyzed with t test and Spearman′s rank correlation. Results The P3 latency in the OSAS group was (359±30) ms (Fz),(365±31) ms (Cz), and in control group was (337±29) ms (Fz), (339±31) ms (Cz) respectively. There was significant difference between the OSAS group and the control group ( P <0.05). No significant differences were seen in P3 amplitude between the two groups. Conclusion Abnormal P3 latency indicated the cognitive dysfunction in the OSAS patients. Nocturnal hypoxaemia may play an important role.

关 键 词：睡眠呼吸暂停 综合征 事件相关电位 OSAS 

分 类 号：R563.9[医药卫生—呼吸系统]