肾移植术后早期肺部感染的多因素分析  

Multi-factor analysis of early pulmonary infections after renal transplantation

作　　者：刘炜[1] 邱丰[1] 王亚伟[1] 凌建煜[1] 

机构地区：[1]上海交通大学医学院附属仁济医院,上海200127

出　　处：《中华器官移植杂志》2011年第7期396-398,共3页Chinese Journal of Organ Transplantation

摘　　要：目的探讨肾移植术后发生肺部感染的危险因素。方法 单中心2006年10月至2010年10月进行肾移植且拥有完整临床资料的早期发生肺部感染者48例作为感染组，另选择手术时间相同、免疫抑制方案相同的48例未发生感染者作为对照组。将发生肺部感染有关的因素作为变量进行单因素及多因素Logistic回归分析。结果单因素分析显示，与肺部感染发生有关的因素分别是抗体诱导、低白蛋白水平、术后1个月泼尼松总量、家庭收入、预防应用磺胺甲嗯唑（SMZ）。消除了混杂因素后采用多因素Logistic回归分析，提示抗体诱导、低白蛋白水平、术后1个月泼尼松总量、预防应用sMZ与肺部感染相关。 结论 肾移植术后早期肺部感染与抗体诱导、术后1个月泼尼松总量呈正相关，与白蛋白水平、预防应用SMZ呈负相关。Objective To find out the risk factors of early pulmonary infections after renal transplantation. Methods The data were collected from 96 patients receiving renal transplantation between Oct. 2006 and Oct. 2010, including 48 cases of early lung infection after renal transplantation as infection group, and 48 patients receiving immunosuppressive regimen at the same period as-control group. Taking the factors of lung infecition as variables, t test or chi-square test was used in univariate analyses whereas logistic regression was used in multivariate analyses. Results Single factor analysis showed that induction therapy, albumin levels, dose of steroid in 1 month after operation, family income and prophylactic SMZ treatment were related to lung infection. Analysis of multiple variables logistic regression revealed that induction therapy, albumin levels, dose of steroid in 1 month after operation and prophylactic SMZ treatment were related to lung infection. Conclusion The correlation analysis indicated that induction therapy and dose of steroid in 1 month after operation have positive correlations with pulmonary infection, while albumin levels and prophylactic SMZ treatment have negative correlations with pulmonary infection.

关 键 词：肾移植 肺部感染 因素 分析 

分 类 号：R563.1[医药卫生—呼吸系统] R699.2[医药卫生—内科学]