多囊卵巢综合征中医证型与药物促排卵效果的相关性研究  

Correlation between Chinese Medicine Syndrome Types of Polycystic Ovary Syndrome and Ovulation Induction Effect

作　　者：赵虹[1,2] 王幸儿[1,2] 张婷[1,2] 王香桂[1,2] 

机构地区：[1]浙江中医药大学附属第一医院 [2]浙江省中医院妇科,杭州310006

出　　处：《中国中西医结合杂志》2011年第7期896-898,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：浙江省中医药管理局(No.2009CA016-A)

摘　　要：目的研究多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者不同中医证型与药物促排卵效果的相关性,探讨其临床意义。方法临床确诊为PCOS患者80例,进行中医辨证分型为肾阴虚型21例,肾阳虚型18例,痰湿郁积型19例、肝郁化热型22例,所有患者每天口服克罗米芬100mg促排卵治疗,连续5天,并对治疗后的排卵结局进行分析比较。结果各证型组患者治疗后周期排卵率及妊娠率从高到低依次为:肾阳虚型(66·7%,22.2%)、肝郁化热型(59.1%,18.2%)、肾阴虚型(28.6%,9.5%)和痰湿郁积型(26.3%,5.3%),其中周期排卵率肾阳虚型及肝郁化热型优于肾阴虚型及痰湿郁积型(P<0·05)。肾阳虚型妊娠率与痰湿郁积型比较,差异有统计学意义(P<0·05)。结论 PCOS痰湿郁积型及肾阴虚型患者药物促排卵效果低于肾阳虚型及肝郁化热型,提示前2个证型患者生殖内分泌异常或代谢异常程度可能重于后2个证型。Objective To study the correlation between Chinese medicine syndrome types of polycystic ovary syndrome（PCOS） and ovulation induction effect,and its clinical significance.Methods Eighty patients with clinically confirmed PCOS were syndrome differentiated as four types,i.e.,Shen-yin deficiency syndrome（21 cases）,Shen-yang deficiency syndrome（18 cases）,phlegm-dampness accumulation syndrome（19 cases）,and Gan-stagnancy transformed heat syndrome（22 cases）.They all took 100 mg clomiphene as the ovulation induction for 5 successive days.Results of ovulation in all patients were analyzed and compared.Results Ovulation induction and the conception rate were sequenced from high to low as follows：Shen-yang deficiency syndrome（66.7%,22.2%）,Gan-stagnancy transformed heat syndrome（59.1%,18.2%）,Shen-yin deficiency syndrome（28.6%,9.5%）,and phlegm-dampness accumulation syndrome（26.3%,5.3%）.Significant difference was shown in ovulation induction results when compared Shen-yang deficiency syndrome with Shen-yin deficiency syndrome and phlegm-dampness accumulation syndrome（P0.05） as well as when compared Gan-stagnancy transformed heat syndrome with Shen-yin deficiency syndrome and phlegm-dampness accumulation syndrome（P0.05）.Significant difference was shown in the conception rate between Shen-yang deficiency syndrome and phlegm-dampness accumulation syndrome（P0.05）.Conclusion The effects of ovulation induction in patients of phlegm-dampness accumulation syndrome and of Shen-yin deficiency syndrome were poorer than those in patients of Shen-yang deficiency syndrome and Gan-stagnancy transformed heat syndrome,which indicated the reproduction endocrine abnormality or the metabolism abnormality degree of the former two syndrome types were more server than the latter two syndrome types.

关 键 词：多囊卵巢综合征 促排卵 中医证型 

分 类 号：R271.9[医药卫生—中西医结合]