胎儿宫内生长迟缓脐血5-羟色胺变化及临床意义  

Change of 5-hydroxytryptamine of cord blood in intrauteine growth retardation.

作　　者：赵文霞[1] 孙欣[1] 赵瑛[1] 赵文艳[2,3] 马秋菊 

机构地区：[1]佳木斯市中心医院妇产科,154002 [2]佳木斯市第二人民医院妇产科 [3]同江市妇幼保健院

出　　处：《中国优生与遗传杂志》1999年第6期56-56,55,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的：探讨胎儿宫内生长迟缓（ＩＵＧＲ） 与５羟色胺含量的关系，方法：采用ＲＦ５０００ 型荧光分光光度计测量法测量正常体重组与ＩＵＧＲ组脐静脉、脐动脉血浆中５ＨＴ 含量。结果：正常新生儿体重组及ＩＵＧＲ，脐静脉、脐动脉之间血浆中５ＨＴ 含量无明显差异（Ｐ＞ ０－０５）ＩＵＧＲ 组脐静脉、脐动脉血浆中５ＨＴ 含量明显高于正常体重组，而且差异非常显著（Ｐ＜ ０－０１）结论：ＩＵＧＲ 脐血管痉挛与５ＨＴ 含量有密切关系。在孕期ＩＵＧＲ给予扩张脐血管治疗非常重要。Objective: To provide evidence to the hypothesis that the involvement of 5-hydroxytryptamine (5-HT) takes part in the pathogenesis of intrauterine growth retardation (IUGR). Methods: Umbilical veins and artery plasma 5-HT from normal body weight group and IUGR group Were Measurel With RF-5000 spectrometry. Results:There is no difference between umbilical veins and artery plasma 5-HT level in normal and IUGR group(p>0.05). The mean plasma 5-HT level in IUGR group was gignificantly higher than that in normal(p<0.01).Conclusion:plasma levels of 5-HT in IUGR were elevated, which might cause cord vessels spasm. It suggests that expanding cord vessels treatment might be useful for IUGR fetus during pregnancy.

关 键 词：胎儿生长迟缓 血清素 分光光度法 脐血 羟色胺 

分 类 号：R714.5[医药卫生—妇产科学]