急性缺氧时一氧化氮和内皮素-1对心肌血流量变化的调节作用  

ROLES OF NITRIC OXIDE AND ENDOTHELIN-1 IN REGULATION OF MYOCARDIAL BLOOD FLOW DURING ACUTE HYPOXIA

作　　者：周玉峰[1] 万强[1] 谢增柱[1] 刘福玉[1] 廖为公 

机构地区：[1]第三军医大学基础部,400038

出　　处：《高原医学杂志》1999年第3期21-24,共4页Journal of High Altitude Medicine

摘　　要：目的：本文旨在探讨一氧化氮和内皮素－１ 在缺氧时对心肌血流量的调节作用。方法：大鼠随机分为平原组和急性缺氧组，用９９ｍ Ｔｃ标记蟾蜍红细胞测定心肌血流量，用Ｇｅｓｓ法和放免法分别测量血浆和心肌ＮＯ－２ 、内皮素－１（ｅｎｄｏｔｈｅｌｉｎ－１，ＥＴ－１）含量、用双波长分光光度法测量一氧化氮合酶（ｎｉｔｒｉｃ ｏｘｉｄｅ ｓｙｎｔｈａｓｅ，ＮＯＳ）活性。结果：急性缺氧导致左、右心室心肌血流量、血浆和心肌ＮＯ－２ 、ＥＴ－１含量、ＮＯＳ活性明显增高（Ｐ＜ ０．０５），左、右心室心肌血管阻力和心肌ＥＴ－１／ＮＯ２ 比值明显下降（Ｐ＜ ０．０５），Ｈｃｔ及心室重量指数无明显变化。结论：急性缺氧时，左、右心室心肌血流量增加，ＥＴ－１、ＮＯ参与隐性缺氧时心肌血流量的调节，以ＮＯ的扩血管作用为主。The article was to investigate the roles of nitric oxide(NO)and endothelin 1(ET-1)in regulation of myocardial blood flow(MBF)during acute hypoxia.Methods:Rats were divided into normoxic group(Control)and acute hypoxia group(AH),MBF were measures with 99m TC radiolabelled toad RBC,the changes of myocardial NO - 2、ET 1 contents,nitric oxide synthase(NOS)activity were observed.Results:Acute hypoxia caused an increase in left and right ventricular MBF,myocardial NO - 2、ET 1 contents and NOS activity,but myocardial vascular resistance,the ratio of ET 1/NO - 2 in the left and right ventricle were decreased,as compared with the control group.Conclusions:NO and ET 1 may be involved in the regulation of MBF in acute hypoxia,but the NO-dependent vasodilation was stronger than the ET 1 dependent vasoconstriction.

关 键 词：缺氧 心肌血流量 一氧化碳 NOS 内皮素1 

分 类 号：R594.3[医药卫生—内科学] R364.4[医药卫生—临床医学]