氧合液对高原失血性休克家兔脂质过氧化损伤的保护作用  

PROTECTIVE EFFECTS OF OXYGENATE SOLUTION ON LIPID PEROXIDATION INJURY IN RABBITTS WITH HEMORRHAGIC SHOCK AT HIGH ALTITUDE

作　　者：周其全[1] 支东学[1] 高丽菊 赖雁 骆礼奎 康步仁 周军 孙利明 

机构地区：[1]解放军兰州医学高等专科学校 [2]青藏兵站部59243部队卫生队 [3]青海省格尔木市人民医院

出　　处：《高原医学杂志》1999年第3期34-38,共5页Journal of High Altitude Medicine

摘　　要：目的：探讨氧合液的抗休克作用和机制。方法：在４ ７００ｍ 的高海拔区实地观察了氧合液对高原失血性休克家兔脂质过氧化损伤的保护作用。结果：氧合液治疗后能明显降低休克动物血浆和组织中ＭＤＡ水平，提高血浆和组织中ＳＯＤ、ＧＳＨ—ＰＸ水平，降低血浆和组织中ＧＳＨ水平。结论：休克后及时使用氧合液治疗能早期纠正体内脂质过氧化损伤，恢复休克机体内氧化与抗氧化新的平衡，从而促进休克机体复苏。To study the protective eff ects of oxygenate solution to lipid peroxydation in base of antishock mechanism at high altitude (4 700m).Methods:A total of 40 rabbitts were divided into 5 groups.Group 1,2,and 3 were given oxygenate solution,vitamin C and naloxone respectively; group 4 served as control and group 5 served as black control.Results:level of MDA and GSH was obviously decreased by the oxygenate solution in plasma and tissue of animals with shock while the level of SOD and GSH_PX were increased.Conclusions:This resserach has demonstrated the oxygenate solution can early play a protective role for lipid peroxidation injury after shock has occuerred,viz.through recovering the balance between oxidation and antioxidation to promote the resuscitation of patients with shock at high altitude.$$$$

关 键 词：高原 失血性休克 氧合液 复苏 LPO 

分 类 号：R605.971[医药卫生—急诊医学]