干细胞在脑性瘫痪治疗中的应用  

Stem cells for cerebral palsy

作　　者：王金刚 尹忠民 闻华 

机构地区：[1]解放军第四六三医院神经外科,辽宁省沈阳市110042

出　　处：《中国组织工程研究与临床康复》2011年第23期4336-4339,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:干细胞在适当条件下可以分化为神经元细胞、星形胶质细胞与少突胶质细胞,可能从根本上改善脑性瘫痪患儿神经元缺失及神经胶质细胞变性,进而改善患儿脑功能障碍,从理论上达到根治目的。目的:回顾性分析不同来源干细胞经不同途径治疗脑性瘫痪患儿的疗效。方法:由第一作者检索1992/2011PubMed数据及万方数据库有关脑性瘫痪的治疗及不同来源干细胞在治疗脑性瘫痪等方面的文献。结果与结论:神经干细胞在动物神经功能损伤中的修复作用已有很多国内外报道,但目前其在人体的临床应用仍处于临床试验阶段。虽然胚胎、骨髓血、胎儿脐带血、脐带来源的干细胞已在部分医院应用到脑性瘫痪患儿中,并取得了初步的疗效,其具体评定标准及长期疗效仍有待进一步随访、观察。BACKGROUND：Stem cells under appropriate conditions can differentiate into neurons,astrocytes and oligodendrocytes,which may radically improve neurons loss and glial cell degeneration in cerebral palsy children,thus to improve brain function in children.OBJECTIVE：To retrospectively analyze the effects of stem cells from different sources on cerebral palsy children.METHODS：The first author searched PubMed and Wanfang databases（1992/2011） for articles concerning therapies for cerebral palsy and stem cells from different sources for cerebral palsy.RESULTS AND CONCLUSION：Neural stem cells for animal nerve injury repair have been a reported,but the clinical application of neural stem cells is still in clinical trials.Although embryonic,bone marrow blood,fetal cord blood,umbilical cord-derived stem cells have been applied to child cerebral palsy in some hospitals and a preliminary efficacy has been obtained,the specific evaluation criteria and long-term effects remain to be further studied.

关 键 词：脑性瘫痪 干细胞 神经干细胞 间充质干细胞 

分 类 号：R318[医药卫生—生物医学工程]