结构脂肪乳剂与物理混合的中/长链脂肪乳剂脂肪酸代谢比较研究  

The comparative study of structured triglyceride and physical mixed MCT/LCT on fatty acid metabolism in healthy subjects

作　　者：唐云[1] 武现生[1] 张大伟[1] 卫勃[1] 陈凛[1] 李荣[1] 

机构地区：[1]解放军总医院普通外科,北京100853

出　　处：《肠外与肠内营养》2011年第4期196-199,共4页Parenteral & Enteral Nutrition

基　　金：吴阶平医学基金会基金资助(06-10-27)

摘　　要：目的:比较结构脂肪乳剂(STG)与物理混合的中/长链脂肪乳剂(MCT/LCT)在人体内的脂肪酸代谢情况。方法:40例健康志愿者随机分为STG组和MCT/LCT组,每组20例。分别于早晨6 h内匀速输注20%力文脂肪乳剂和20%力保肪宁脂肪乳剂1.0 g/(kg.次)。并于给药前和给药后2、4、6和24 h留取血标本测定血清三酰甘油(TG),采用气质联用色谱法测定血清中链脂肪酸(C8∶0,C10∶0)和长链脂肪酸(C18∶2n-6,C18∶3n-3,C20∶4n-6)。结果:与MCT/LCT组比,STG组血清TG处于较低的平稳状态;血清中链脂肪酸(C8∶0+C10∶0)水平较低,水解速度较平稳;血清长链脂肪酸(C18∶2n-6、C18∶3n-3、C20∶4n-6)水平也较低,水解速度也较平稳,差异均有统计学意义。结论:STG比MCT/LCT的脂肪酸代谢效果更好。Objective：The purpose of study was to compare fatty acid metabolism of structured triglyceride and physical mixed MCT/LCT in healthy subjects.Methods：Totally,40 healthy subjects were randomly allocated into STG group（n=20）and MCT/LCT group（n=20）.The emulsions used in this study were 20% Structolipid and 20% Lipofundin respectively.6-h infusions of emulsion（1.0 g triglyceride/kg body wt） were from 6：00 Am to12：00 Am.Blood samples were taken before（time zero）and at timed intervals during（0-6 h）and after（24 h） emulsion infusion.Serum triglyceride concentrations and individual fatty acid profiles（C8∶0,C10∶0,C18∶2n-6,C18∶3n-3,C20∶4n-6） were analyzed.Results：The serum triglyceride concentrations was lower and more steady-state during STG infusion than during MCT/LCT infusion（P0.05）.C8∶0＋ C10∶0 was lower and more steady-state in rates of hydrolysis during STG infusion than during MCT/LCT infusion（P0.05,P0.01）.C18∶2n-6,C18∶3n-3,C20∶4n-6 were also lower（P0.05,P0.01）.Conclusion：The fatty acid metabolism in structured triglyceride is better than in physical mixed MCT/LCT.

关 键 词：结构脂肪乳剂 物理混合中/长链脂肪乳剂 脂肪酸 代谢 

分 类 号：R459.3[医药卫生—治疗学] R589.2[医药卫生—临床医学]