复方α-酮酸联合氯沙坦钾对糖尿病肾病的疗效分析  

The effect of α-keto acid on diabetes nephropathy

作　　者：杨方才 

机构地区：[1]宁海第一医院营养科,浙江宁海315600

出　　处：《肠外与肠内营养》2011年第4期228-230,234,共4页Parenteral & Enteral Nutrition

摘　　要：目的:评价在低蛋白饮食和氯沙坦钾治疗基础上用复方α-酮酸对糖尿病肾病的影响。方法:选择62例Ⅲ、Ⅳ期2型糖尿病肾病病人,在低蛋白饮食加氯沙坦钾基础上控制血压、血糖和血脂平稳后,随机分为观察组(32例)和对照组(30例),观察组病人给予复方α-酮酸,两组均随访观察24周。结果:两组病人治疗后24h尿清蛋白量均较治疗前明显减少,观察组优于对照组,差异有显著性意义(P<0.01);两组病人治疗前后血尿素氮(BUN)、肌酐(Cr)、肾小球滤过率等均无明显改变;观察组病人治疗前后各项营养指标均无明显改变,而对照组病人清蛋白、前清蛋白、血红蛋白和上臂肌围均有明显下降(P<0.05);观察组病人治疗后收缩压较治疗前明显下降(P<0.05)。结论:复方α-酮酸联合氯沙坦钾能更有效地减少尿蛋白,可有利于控制血压,延缓肾功能进一步损害,可有效地避免低蛋白饮食造成的营养不良。Objective：To evaluate the effect of α-keto acid on diabetes nephroqathy.Methods：Under the use of low-protein diet and Losartan Potassium,sixty-two patients with Ⅲ,Ⅳ plase diabetie nephropathy were divided into two groups,experimental group（n=32）（α-keto acid for 24 weeks） and control group（n=30）.Results：After treatment,the 24 h urine albumin excretion decreased significantly in both of the two groups,and the effect in experimental group was better than in control groups.There were no obvions change in the index of nutrition in experimental group,but ALB,PA,Hb and MAMC in the control groups were decreessed significantly（P0.05）.Couclusion：The α-keto acid can reduce urine albumin more effectively,which is beneficial to the control of blood pressure,renal damage and malnutrition.

关 键 词：复方Α-酮酸 氯沙坦钾 低蛋白质饮食 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]